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Potent, selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Chen et al (1997) Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL 28170. Brain Res. 769 188 PMID: 9374290
Li et al (1998) Postischemic treatment with a calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia. Neurosci.Lett. 247 17 PMID: 9637399
Mehdi (1991) Cell-penetrating inhibitor of calpain. TiBS 16 150 PMID: 1877091
Ai et al (2007) Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J.Neurotrauma 24 960 PMID: 17600513
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Keywords: MDL 28170, MDL 28170 supplier, Potent, selective, calpain, cathepsin, B, inhibitors, inhibits, Proteinases, Proteases, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, MDL28170, Calpains, Cathepsin, 1146, Tocris Bioscience
3 Citations for MDL 28170
Citations are publications that use Tocris products. Selected citations for MDL 28170 include:
Schubert et al (2014) Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. Acta Neuropathol 128 835 PMID: 25341622
Zechel et al (2016) Thalamo-cortical axons regulate the radial dispersion of neocortical GABAergic interneurons. Elife 5 PMID: 27935475
Bill et al (2015) ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. J Neurosci 6 9173 PMID: 25823819
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