MDL 28170

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Cat.No. 1146 - MDL 28170 | C22H26N2O4 | CAS No. 88191-84-8
Description: Potent, selective calpain and cathepsin B inhibitor
Chemical Name: N-[N-[(Phenylmethoxy)carbonyl]-L-valyl]-phenylalaninal
Purity: ≥95% (HPLC)
Datasheet
Citations (2)

Biological Activity

Potent, selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo.

Technical Data

M. Wt 382.45
Formula C22H26N2O4
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 88191-84-8
PubChem ID 11199915
InChI Key NGBKFLTYGSREKK-ANYOKISRSA-N
Smiles O=C(N[C@@H]([C@H](C)C)C(NC(CC2=CC=CC=C2)C([H])=O)=O)OCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 382.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.07 mL 26.15 mL
5 mM 0.52 mL 2.61 mL 5.23 mL
10 mM 0.26 mL 1.31 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Chen et al (1997) Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL 28170. Brain Res. 769 188 PMID: 9374290

Li et al (1998) Postischemic treatment with a calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia. Neurosci.Lett. 247 17 PMID: 9637399

Mehdi (1991) Cell-penetrating inhibitor of calpain. TiBS 16 150 PMID: 1877091

Ai et al (2007) Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J.Neurotrauma 24 960 PMID: 17600513


If you know of a relevant reference for MDL 28170, please let us know.

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2 Citations for MDL 28170

Citations are publications that use Tocris products. Selected citations for MDL 28170 include:

Bill et al (2015) ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. J Neurosci 6 9173 PMID: 25823819

Schubert et al (2014) Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. Acta Neuropathol 128 835 PMID: 25341622


Do you know of a great paper that uses MDL 28170 from Tocris? If so please let us know.

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