MDL 28170

Pricing Availability Delivery Time Qty
Cat.No. 1146 - MDL 28170 | C22H26N2O4 | CAS No. 88191-84-8
Description: Potent, selective calpain and cathepsin B inhibitor
Chemical Name: N-[N-[(Phenylmethoxy)carbonyl]-L-valyl]-phenylalaninal
Purity: ≥95% (HPLC)
Citations (2)

Biological Activity

Potent, selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo.

Technical Data

M. Wt 382.45
Formula C22H26N2O4
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 88191-84-8
PubChem ID 11199915
Smiles O=C(N[C@@H]([C@H](C)C)C(NC(CC2=CC=CC=C2)C([H])=O)=O)OCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 38.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 382.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.07 mL 26.15 mL
5 mM 0.52 mL 2.61 mL 5.23 mL
10 mM 0.26 mL 1.31 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet


References are publications that support the products' biological activity.

Chen et al (1997) Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL 28170. Brain Res. 769 188 PMID: 9374290

Li et al (1998) Postischemic treatment with a calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia. Neurosci.Lett. 247 17 PMID: 9637399

Mehdi (1991) Cell-penetrating inhibitor of calpain. TiBS 16 150 PMID: 1877091

Ai et al (2007) Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J.Neurotrauma 24 960 PMID: 17600513

If you know of a relevant reference for MDL 28170, please let us know.

View Related Products by Product Action

View all Calcium-Sensitive Protease Inhibitors

Keywords: MDL 28170, supplier, Potent, selective, calpain, cathepsin, B, inhibitors, inhibits, Proteinases, Proteases, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, MDL28170, Calcium-Sensitive, Proteases, Calpains, Cathepsin, Calcium-Sensitive, Proteases, Tocris Bioscience

2 Citations for MDL 28170

Citations are publications that use Tocris products. Selected citations for MDL 28170 include:

Bill et al (2015) ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. J Neurosci 6 9173 PMID: 25823819

Schubert et al (2014) Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. Acta Neuropathol 128 835 PMID: 25341622

Do you know of a great paper that uses MDL 28170 from Tocris? If so please let us know.

Reviews for MDL 28170

There are currently no reviews for this product. Be the first to review MDL 28170 and earn rewards!

Have you used MDL 28170?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review