MDL 28170

Discontinued Product

MDL 28170 (Cat. No. 1146) has been withdrawn from sale for commercial reasons.
Cat.No. 1146 - MDL 28170 | C22H26N2O4 | CAS No. 88191-84-8
Description: Potent, selective calpain and cathepsin B inhibitor
Chemical Name: N-[N-[(Phenylmethoxy)carbonyl]-L-valyl]-phenylalaninal
Purity: ≥95% (HPLC)
Citations (3)

Biological Activity

Potent, selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo.

Technical Data

M. Wt 382.45
Formula C22H26N2O4
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 88191-84-8
PubChem ID 11199915
Smiles O=C(N[C@@H]([C@H](C)C)C(NC(CC2=CC=CC=C2)C([H])=O)=O)OCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:


References are publications that support the biological activity of the product.

Chen et al (1997) Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL 28170. Brain Res. 769 188 PMID: 9374290

Li et al (1998) Postischemic treatment with a calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia. Neurosci.Lett. 247 17 PMID: 9637399

Mehdi (1991) Cell-penetrating inhibitor of calpain. TiBS 16 150 PMID: 1877091

Ai et al (2007) Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J.Neurotrauma 24 960 PMID: 17600513

View Related Products by Product Action

View all Calcium-Sensitive Protease Inhibitors

Keywords: MDL 28170, MDL 28170 supplier, Potent, selective, calpain, cathepsin, B, inhibitors, inhibits, Proteinases, Proteases, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, MDL28170, Calpains, Cathepsin, 1146, Tocris Bioscience

3 Citations for MDL 28170

Citations are publications that use Tocris products. Selected citations for MDL 28170 include:

Schubert et al (2014) Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. Acta Neuropathol 128 835 PMID: 25341622

Zechel et al (2016) Thalamo-cortical axons regulate the radial dispersion of neocortical GABAergic interneurons. Elife 5 PMID: 27935475

Bill et al (2015) ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. J Neurosci 6 9173 PMID: 25823819

Reviews for MDL 28170

There are currently no reviews for this product. Be the first to review MDL 28170 and earn rewards!

Have you used MDL 28170?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review