Maritoclax

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Cat.No. 5368 - Maritoclax | C22H12Cl4N2O4 | CAS No. 1227962-62-0
Description: Mcl-1 inhibitor; proapoptotic
Chemical Name: 1,1'-(4,4',5,5'-Tetrachloro[1,3'-bi-1H-pyrrole]-2,2'-diyl)bis[1-2-hydroxyphenyl)methanone
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Mcl-1 inhibitor; disrupts Mcl-1-Bim interaction and induces Mcl-1 proteasomal degradation. Exhibits no effect on Bcl-XL-Bim interaction. Selectively induces apoptosis in Mcl-1-dependent K562 leukemia cells. Sensitizes K562 and Raji cells to ABT-737-induced apoptosis.

Technical Data

M. Wt 510.15
Formula C22H12Cl4N2O4
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1227962-62-0
PubChem ID 24797083
InChI Key QYPJBTMRYKRTFG-UHFFFAOYSA-N
Smiles ClC1=C(Cl)C(N2C(C(C4=C(O)C=CC=C4)=O)=CC(Cl)=C2Cl)=C(C(C3=C(O)C=CC=C3)=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.01 100
ethanol 25.51 50

Preparing Stock Solutions

The following data is based on the product molecular weight 510.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.96 mL 9.8 mL 19.6 mL
5 mM 0.39 mL 1.96 mL 3.92 mL
10 mM 0.2 mL 0.98 mL 1.96 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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References

References are publications that support the biological activity of the product.

Doi et al (2012) Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation. J.Biol.Chem. 287 10224 PMID: 22311987

Pandey et al (2013) Proteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cells. PLoS ONE 8 e78570 PMID: 24223823


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Citations for Maritoclax

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Literature in this Area

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Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Maritoclax

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.