You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for A 1210477
A 1210477 is a selective, high affinity Mcl-1 inhibitor (Ki = 454 pM). Disrupts Mcl-BIM complexes (IC50 in low μM range). Also inhibits Mcl-1NOXA interactions. Exhibits no effect on Bcl-XL-Bim or Bcl-X-BCL-Xs interactions. Induces apoptosis in multiple myeloma and non-small cell lung cancer cell lines and exhibits a synergistic effect with NavitoclaxTM to induce apoptosis in vitro. Cell permeable.
Technical Data for A 1210477
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for A 1210477
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||1.7||2 with gentle warming|
Preparing Stock Solutions for A 1210477
The following data is based on the product molecular weight 850.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.02 mM||58.82 mL||294.1 mL||588.21 mL|
|0.1 mM||11.76 mL||58.82 mL||117.64 mL|
|0.2 mM||5.88 mL||29.41 mL||58.82 mL|
|1 mM||1.18 mL||5.88 mL||11.76 mL|
References for A 1210477
References are publications that support the biological activity of the product.
Bruncko et al (2015) Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity. J.Med.Chem. 58 2180 PMID: 25679114
Leverson et al (2015) Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax). Cell Death Dis. 6 e1590 PMID: 25590800
If you know of a relevant reference for A 1210477, please let us know.
View Related Products by Product Action
Keywords: A 1210477, A 1210477 supplier, A1210477, Mcl-1, inhibitors, inhibits, apoptosis, proapoptotic, selective, high, affinity, multiple, myeloma, non-small, cell, lung, cancer, Bcl-2, Family, 6409, Tocris Bioscience
Citations for A 1210477
Citations are publications that use Tocris products.
Currently there are no citations for A 1210477. Do you know of a great paper that uses A 1210477 from Tocris? Please let us know.
Reviews for A 1210477
There are currently no reviews for this product. Be the first to review A 1210477 and earn rewards!
Have you used A 1210477?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.