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Discontinued Product
MAP4 (Cat. No. 0711) has been withdrawn from sale for commercial reasons.
Description: Potent group II mGlu agonist; also group III mGlu antagonist
Chemical Name: (S)-2-Amino-2-methyl-4-phosphonobutanoic acid
Purity: ≥96% (HPLC)
Biological Activity for MAP4
MAP4 is a selective group III metabotropic glutamate receptor antagonist in some electrophysiological systems. Group II/group III agonist in certain neurochemical systems.
Technical Data for MAP4
| M. Wt | 197.13 |
| Formula | C5H12NO5P |
| Storage | Store at RT |
| Purity | ≥96% (HPLC) |
| CAS Number | 157381-42-5 |
| PubChem ID | 1795545 |
| InChI Key | HONKEGXLWUDTCF-YFKPBYRVSA-N |
| Smiles | N[C@](CCP(O)(O)=O)(C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MAP4
References for MAP4
References are publications that support the biological activity of the product.
Jane et al (1994) Actions of two new sub-type selective metabotropic glutamate receptor antagonists in the neonatal rat spinal cord. Br.J.Pharmacol. 112 809 PMID: 7921606
Kemp et al (1996) Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices. Eur.J.Pharmacol. 309 79 PMID: 8864697
Salt and Eaton (1995) Distinct presynaptic metabotropic receptors for L-AP4 and CCGl on GABAergic terminals: pharmacological evidence using novel α-methyl derivative mGluR antagonists, MAP4 and MCCG, in the rat thalamus in vivo. Neuroscience 65 5 PMID: 7753406
Sekiyama et al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 117 1493 PMID: 8730745
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Keywords: MAP4, MAP4 supplier, Potent, group, II, mGlur, agonists, specific, III, antagonists, Selective, potent, Group, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, mGlu4, mGluR4, mGlu6, mGluR6, mGlu7, mGluR7, mGlu8, mGlkuR8, (Metabotropic), 0711, Tocris Bioscience
1 Citation for MAP4
Citations are publications that use Tocris products. Selected citations for MAP4 include:
Piet et al (2004) Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk. J Neurosci 101 2151 PMID: 14766975
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