LY 307452

Discontinued Product

Unfortunately LY 307452 (Cat. No. 1474) has been withdrawn from sale for commercial reasons.
Cat.No. 1474 - LY 307452 | CAS No. 174393-13-6
Description: Selective group II mGlu antagonist
Chemical Name: (4S)-4-(4,4-Diphenylbutyl)-L-glutamic acid

Biological Activity

Selective and competitive group II metabotropic glutamate receptor antagonist. Centrally active following systemic administration in vivo.

Licensing Information

Sold with the permission of Eli Lilly and Company.

Technical Data

M. Wt 355.43
Storage Desiccate at +4°C
CAS Number 174393-13-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 355.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.07 mL 28.13 mL
5 mM 0.56 mL 2.81 mL 5.63 mL
10 mM 0.28 mL 1.41 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Certificate of Analysis is currently unavailable on-line.
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Safety Datasheet


References are publications that support the products' biological activity.

Li et al (1999) Type I and II metabotropic glutamate receptor agonists and antagonists evoke cardiovascular effects after intrathecal administration in conscious rats. Br.J.Pharmacol. 128 823 PMID: 10516668

Schoepp et al (1997) LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors. Neuropharmacology 36 1 PMID: 9144636

Wermuth et al (1996) (2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)-pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase. J.Med.Chem. 39 814 PMID: 8632404

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Keywords: LY 307452, supplier, Glutamate, (Metabotropic), Group, II, Receptors, Glutamate, (Metabotropic), Group, II, Receptors, Tocris Bioscience

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