Selective and competitive group II metabotropic glutamate receptor antagonist. Centrally active following systemic administration in vivo.
Sold with the permission of Eli Lilly and Company.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
References are publications that support the biological activity of the product.
Li et al (1999) Type I and II metabotropic glutamate receptor agonists and antagonists evoke cardiovascular effects after intrathecal administration in conscious rats. Br.J.Pharmacol. 128 823 PMID: 10516668
Schoepp et al (1997) LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors. Neuropharmacology 36 1 PMID: 9144636
Wermuth et al (1996) (2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)-pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase. J.Med.Chem. 39 814 PMID: 8632404
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Keywords: LY 307452, LY 307452 supplier, Glutamate, (Metabotropic), Group, II, Receptors, 1474, Tocris Bioscience
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