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Submit ReviewLY 307452
Discontinued Product
LY 307452 (Cat. No. 1474) has been withdrawn from sale for commercial reasons.
Description: Selective group II mGlu antagonist
Chemical Name: (4S)-4-(4,4-Diphenylbutyl)-L-glutamic acid
Biological Activity for LY 307452
Selective and competitive group II metabotropic glutamate receptor antagonist. Centrally active following systemic administration in vivo.
Licensing Information
Sold with the permission of Eli Lilly and Company.
Technical Data for LY 307452
| M. Wt | 355.43 |
| Storage | Desiccate at +4°C |
| CAS Number | 174393-13-6 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LY 307452
Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service
Please contact Customer Service
References for LY 307452
References are publications that support the biological activity of the product.
Li et al (1999) Type I and II metabotropic glutamate receptor agonists and antagonists evoke cardiovascular effects after intrathecal administration in conscious rats. Br.J.Pharmacol. 128 823 PMID: 10516668
Schoepp et al (1997) LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors. Neuropharmacology 36 1 PMID: 9144636
Wermuth et al (1996) (2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)-pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase. J.Med.Chem. 39 814 PMID: 8632404
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Keywords: LY 307452, LY 307452 supplier, Glutamate, (Metabotropic), Group, II, Receptors, 1474, Tocris Bioscience
Citations for LY 307452
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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