LY 307452

Discontinued Product

LY 307452 (Cat. No. 1474) has been withdrawn from sale for commercial reasons.
Description: Selective group II mGlu antagonist
Chemical Name: (4S)-4-(4,4-Diphenylbutyl)-L-glutamic acid
Literature (4)

Biological Activity for LY 307452

Selective and competitive group II metabotropic glutamate receptor antagonist. Centrally active following systemic administration in vivo.

Licensing Information

Sold with the permission of Eli Lilly and Company.

Technical Data for LY 307452

M. Wt 355.43
Storage Desiccate at +4°C
CAS Number 174393-13-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for LY 307452

Certificate of Analysis is currently unavailable on-line.
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Keywords: LY 307452, LY 307452 supplier, Glutamate, (Metabotropic), Group, II, Receptors, 1474, Tocris Bioscience

Citations for LY 307452

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Currently there are no citations for LY 307452.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.