LY 303511

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Cat.No. 2418 - LY 303511 | C19H18N2O2 | CAS No. 154447-38-8
Description: Negative control of LY 294002 (Cat. No. 1130)
Chemical Name: 2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

Negative control compound for LY 294002 PI 3-kinase inhibitory activity. Blocks voltage-gated potassium (Kv) channels (IC50 = 64.6 μM) and inhibits IL-1β-stimulated NF-κB activation, attenuating MCP-1 expression. Antiproliferative. Also inhibits the BET bromodomain proteins BRD2, BRD3 and BRD4.

Active Analog also available.

Compound Libraries

LY 303511 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 306.36
Formula C19H18N2O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 154447-38-8
PubChem ID 3971
InChI Key NGAGMBNBKCDCDJ-UHFFFAOYSA-N
Smiles O=C1C=C(OC2=C(C=CC=C12)C1=CC=CC=C1)N1CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 30.64 100
DMSO 30.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 306.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.26 mL 16.32 mL 32.64 mL
5 mM 0.65 mL 3.26 mL 6.53 mL
10 mM 0.33 mL 1.63 mL 3.26 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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References

References are publications that support the biological activity of the product.

El-kholy et al (2003) The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks KV currents via a direct mechanism. FASEB J. 17 720 PMID: 12586735

Choi et al (2004) LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism. FEBS Letters. 559 141 PMID: 14960322

Kristof et al (2005) LY303511 (2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target rapamycin (mTOR)- and non-mTOR-dependent mechanisms. J.Pharmacol.Exp.Ther. 314 1134 PMID: 15923340


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Keywords: LY 303511, LY 303511 supplier, Negative, control, LY, 294002, LY294002, PI3K, Phosphoinositide, PI, 3-Kinases, PIP2, Inositol, Lipids, LY303511, 3-Kinase, Bromodomains, 2418, Tocris Bioscience

Citations for LY 303511

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