LY 215840

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Cat.No. 1523 - LY 215840 | C24H33N3O2 | CAS No. 137328-52-0
Description: 5-HT2/5-HT7 antagonist
Chemical Name: [8β(1S,2R)]-N-(2-Hydroxycyclopentyl)-6-methyl-1-(1-methylethyl)-ergoline-8-carboxamide
Purity: ≥98% (HPLC)
Citations (4)
Reviews (1)
Literature (3)

Biological Activity for LY 215840

LY 215840 is a 5-HT2/5-HT7 receptor antagonist. Reduces stimulatory effect of serotonin on aldosterone secretion; also reduces 5-HT-induced cAMP formation (pKB = 8.26).

Technical Data for LY 215840

M. Wt 395.54
Formula C24H33N3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 137328-52-0
PubChem ID 9822062
Smiles CC(C)N2C1=C(C(C[C@]4([H])[C@@]([H])3C[C@@H]([C@@](N[C@@H]5[C@H](O)CCC5)=O)CN4C)=C2)C3=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LY 215840

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.55 100
ethanol 9.89 25

Preparing Stock Solutions for LY 215840

The following data is based on the product molecular weight 395.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.64 mL 25.28 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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References for LY 215840

References are publications that support the biological activity of the product.

Cushing et al (1996) LY215840, a high-affinity 5-HT7 receptor ligand, blocks serotonin-induced relaxation in canine coronary artery. J.Pharmacol.Exp.Ther. 277 1560 PMID: 8667223

Lenglet et al (2002) Activation of 5-HT7 receptor in rat glomerulosa cells is associated with an increase in adenylyl cyclase activity and calcium influx through T-type calcium channels. Endocrinology 143 1748 PMID: 11956157

Louiset et al (2006) Expression of serotonin7 receptor and coupling of ectopic receptors to protein kinase A and ionic currents in adrenocorticotropin-independent macronodular adrenal hyperplasia causing Cushing's syndrome. J.Clin.Endocrinol.Metab. 91 4578 PMID: 16954157

If you know of a relevant reference for LY 215840, please let us know.

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Keywords: LY 215840, LY 215840 supplier, LY215840, 5-ht, serotonin, receptors, antagonists, 5ht2, 5ht7, 5-hydroxytryptamine, Non-selective, 5-HT, 5-HT2, 5-HT7, Receptors, 1523, Tocris Bioscience

4 Citations for LY 215840

Citations are publications that use Tocris products. Selected citations for LY 215840 include:

Chan et al (2016) A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors. PLoS Pathog 12 e1005651 PMID: 27187180

Du et al (2015) Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J 29 2194 PMID: 25667222

Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. PLoS Negl Trop Dis 3 e00103 PMID: 25692021

Chan et al (2015) Ergot Alkaloids (Re)generate New Leads as Antiparasitics. BMC Neurosci 9 e0004063 PMID: 26367744

Do you know of a great paper that uses LY 215840 from Tocris? Please let us know.

Reviews for LY 215840

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5-HT has a potential for relaxant.
By Anonymous on 02/18/2020
Assay Type: In Vivo
Species: Rat

1nM 5-HT7 receptor antagonists LY215840

PMID: 25692021
review image

Literature in this Area

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