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Submit ReviewLP 922761
Description: Potent AAK1 inhibitor; peripherally restricted
Chemical Name: tert-Butyl (2-((3-(4-carbamoylphenyl)imidazo[1,2-b]pyridazin-6-yl)amino)ethyl)(methyl)carbamate
Purity: ≥98% (HPLC)
Biological Activity for LP 922761
LP 922761 is a potent AAK1 inhibitor (IC50 values are 4.8 and 7.6 nM in enzyme and cell assays, respectively). Exhibits some selectivity for AAK1 over BIKE, and exhibits no significant activity at opioid, adrenergic α2 or GABAA receptors. Orally bioavailable. Peripherally restricted.
Compound Libraries for LP 922761
LP 922761 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.
Technical Data for LP 922761
| M. Wt | 410.47 |
| Formula | C21H26N6O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1454808-95-7 |
| PubChem ID | 86696405 |
| InChI Key | YNQNYIHMAZLJAV-UHFFFAOYSA-N |
| Smiles | CN(C(OC(C)(C)C)=O)CCNC1=NN2C(C=C1)=NC=C2C3=CC=C(C(N)=O)C=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LP 922761
References for LP 922761
References are publications that support the biological activity of the product.
Kostich et al (2016) Inhibition of AAK1 kinase as a novel therapeutic approach to treat neuropathic pain. J.Pharmacol.Exp.Ther. 358 371 PMID: 27411717
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Keywords: LP 922761, LP 922761 supplier, LP922761, AAK1, adapter, protein-2, AP2, associated, kinase, 1, potent, inhibitors, inhibits, peripherally, restricted, orally, bioavailable, Other, Kinases, 6229, Tocris Bioscience
Citations for LP 922761
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Currently there are no citations for LP 922761.
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