LP 922761

Pricing Availability   Qty
Description: Potent AAK1 inhibitor; peripherally restricted
Chemical Name: tert-Butyl (2-((3-(4-carbamoylphenyl)imidazo[1,2-b]pyridazin-6-yl)amino)ethyl)(methyl)carbamate
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for LP 922761

LP 922761 is a potent AAK1 inhibitor (IC50 values are 4.8 and 7.6 nM in enzyme and cell assays, respectively). Exhibits some selectivity for AAK1 over BIKE, and exhibits no significant activity at opioid, adrenergic α2 or GABAA receptors. Orally bioavailable. Peripherally restricted.

Compound Libraries for LP 922761

LP 922761 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for LP 922761

M. Wt 410.47
Formula C21H26N6O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1454808-95-7
PubChem ID 86696405
Smiles CN(C(OC(C)(C)C)=O)CCNC1=NN2C(C=C1)=NC=C2C3=CC=C(C(N)=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LP 922761

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.52 50

Preparing Stock Solutions for LP 922761

The following data is based on the product molecular weight 410.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.87 mL 24.36 mL 48.72 mL
2.5 mM 0.97 mL 4.87 mL 9.74 mL
5 mM 0.49 mL 2.44 mL 4.87 mL
25 mM 0.1 mL 0.49 mL 0.97 mL

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References for LP 922761

References are publications that support the biological activity of the product.

Kostich et al (2016) Inhibition of AAK1 kinase as a novel therapeutic approach to treat neuropathic pain. J.Pharmacol.Exp.Ther. 358 371 PMID: 27411717

If you know of a relevant reference for LP 922761, please let us know.

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Citations for LP 922761

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