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Biological Activity for LP 922761
LP 922761 is a potent AAK1 inhibitor (IC50 values are 4.8 and 7.6 nM in enzyme and cell assays, respectively). Exhibits some selectivity for AAK1 over BIKE, and exhibits no significant activity at opioid, adrenergic α2 or GABAA receptors. Orally bioavailable. Peripherally restricted.
Technical Data for LP 922761
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LP 922761
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for LP 922761
The following data is based on the product molecular weight 410.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.87 mL||24.36 mL||48.72 mL|
|2.5 mM||0.97 mL||4.87 mL||9.74 mL|
|5 mM||0.49 mL||2.44 mL||4.87 mL|
|25 mM||0.1 mL||0.49 mL||0.97 mL|
References for LP 922761
References are publications that support the biological activity of the product.
Kostich et al (2016) Inhibition of AAK1 kinase as a novel therapeutic approach to treat neuropathic pain. J.Pharmacol.Exp.Ther. 358 371 PMID: 27411717
If you know of a relevant reference for LP 922761, please let us know.
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Citations for LP 922761
Citations are publications that use Tocris products.
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Reviews for LP 922761
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Literature in this Area
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