Liproxstatin-1 hydrochloride

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Cat.No. 6113 - Liproxstatin-1 hydrochloride | C19H21ClN4.HCl
Description: Potent ferroptosis inhibitor
Chemical Name: N-[(3-Chlorophenyl)methyl]spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Potent ferroptosis inhibitor (IC50 = 22 nM). Protects human renal proximal tubule cells from 1S,3R-RSL3 (Cat.No. 6118) -induced cell death in vitro. Inhibits acute renal failure and prolongs survival in Gpx4 knockdown mice. Also mitigates tissue damage in an in vivo hepatic ischemia/reperfusion model.

Technical Data

M. Wt 377.31
Formula C19H21ClN4.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
Smiles ClC1=CC=CC(CNC2=NC3=CC=CC=C3NC24CCNCC4)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 377.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.25 mL 26.5 mL
5 mM 0.53 mL 2.65 mL 5.3 mL
10 mM 0.27 mL 1.33 mL 2.65 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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References

References are publications that support the biological activity of the product.

Friedmann Angeli et al (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat.Cell.Biol. 16 1180 PMID: 25402683


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Citations for Liproxstatin-1 hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

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  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
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Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
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MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Alzheimer's

Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

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Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Pathways for Liproxstatin-1 hydrochloride

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.