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1S,3R-RSL3

Cat. No. 6118 Submit a Review Datasheet / COA / SDS
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Cat.No. 6118 - 1S,3R-RSL3 | C23H21ClN2O5 | CAS No. 1219810-16-8
Description: Induces ferroptosis; inhibits glutathione peroxidase 4 (GPX4)
Chemical Name: (1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Glutathione peroxidase 4 (GPX4) inhibitor. Induces ferroptosis. Increases lipid peroxidase levels in vitro. Inhibits tumor formation and progression in vivo.

Licensing Information

Sold with the permission of Columbia University.

Technical Data

M. Wt 440.88
Formula C23H21ClN2O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1219810-16-8
PubChem ID 16398939
InChI Key TXJZRSRTYPUYRW-YMXDCFFPSA-N
Smiles COC([C@H]1CC2=C([C@H](C3=CC=C(C(OC)=O)C=C3)N1C(CCl)=O)NC4=CC=CC=C24)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.09 100

Preparing Stock Solutions

The following data is based on the product molecular weight 440.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.34 mL 22.68 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.13 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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References

References are publications that support the biological activity of the product.

Yang et al (2014) Regulation of ferroptotic cancer cell death by GPX4. Cell. 156 317 PMID: 24439385

Yang et al (2016) Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc.Natl.Acad.Sci.U.S.A. 113 E4966 PMID: 27506793

Feng & Stockwell et al (2018) Unsolved mysteries: How does lipid peroxidation cause ferroptosis? PLoS. Biol. 16 e2006203 PMID: 29795546

If you know of a relevant reference for 1S,3R-RSL3, please let us know.

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