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1S,3R-RSL3

Cat. No. 6118 4 Citations Submit a Review Datasheet / COA / SDS
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Description: Inhibits glutathione peroxidase (GPX4); induces ferroptosis
Chemical Name: (1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for 1S,3R-RSL3

1S,3R-RSL3 is a glutathione peroxidase 4 (GPX4) inhibitor. Induces ferroptosis. Increases lipid peroxidase levels in vitro. Inhibits tumor formation and progression in vivo.

Negative control 1R,3R-RSL3 (Cat. No. 6687) also available.

Licensing Information

Sold with the permission of Columbia University.

Technical Data for 1S,3R-RSL3

M. Wt 440.88
Formula C23H21ClN2O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1219810-16-8
PubChem ID 16398939
InChI Key TXJZRSRTYPUYRW-YMXDCFFPSA-N
Smiles COC([C@H]1CC2=C([C@H](C3=CC=C(C(OC)=O)C=C3)N1C(CCl)=O)NC4=CC=CC=C24)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 1S,3R-RSL3

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.09 100

Preparing Stock Solutions for 1S,3R-RSL3

The following data is based on the product molecular weight 440.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.34 mL 22.68 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.13 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Product Datasheets for 1S,3R-RSL3

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for 1S,3R-RSL3

References are publications that support the biological activity of the product.

Yang et al (2014) Regulation of ferroptotic cancer cell death by GPX4. Cell. 156 317 PMID: 24439385

Yang et al (2016) Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc.Natl.Acad.Sci.U.S.A. 113 E4966 PMID: 27506793

Feng & Stockwell et al (2018) Unsolved mysteries: How does lipid peroxidation cause ferroptosis? PLoS. Biol. 16 e2006203 PMID: 29795546

If you know of a relevant reference for 1S,3R-RSL3, please let us know.

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Keywords: 1S,3R-RSL3, 1S,3R-RSL3 supplier, Ferroptosis, activator, activates, glutathione, peroxidase, 4, GPX4, inhibitors, inhibits, Other, Reductase, 6118, Tocris Bioscience

4 Citations for 1S,3R-RSL3

Citations are publications that use Tocris products. Selected citations for 1S,3R-RSL3 include:

Eva et al (2020) Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis. Cancer Cell 37 55-70.e15 PMID: 31935372

Bi et al (2019) Metadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death Dis 10 682 PMID: 31527591

Stefan et al (2019) Combined Knockout of RIPK3 and MLKL Reveals Unexpected Outcome in Tissue Injury and Inflammation. Front Cell Dev Biol 7 19 PMID: 30842945

Guido R Y et al (2023) Effect of erythrophagocytosis-induced ferroptosis during angiogenesis in atherosclerotic plaques. Angiogenesis PMID: 37120604

Do you know of a great paper that uses 1S,3R-RSL3 from Tocris? Please let us know.

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