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Description: Inhibits glutathione peroxidase (GPX4); induces ferroptosis
Chemical Name: (1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate
Purity: ≥98% (HPLC)
Biological Activity for 1S,3R-RSL3
1S,3R-RSL3 is a glutathione peroxidase 4 (GPX4) inhibitor. Induces ferroptosis. Increases lipid peroxidase levels in vitro. Inhibits tumor formation and progression in vivo.
Negative control 1R,3R-RSL3 (Cat. No. 6687) also available.
Licensing Information
Sold with the permission of Columbia University.
Technical Data for 1S,3R-RSL3
| M. Wt | 440.88 |
| Formula | C23H21ClN2O5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1219810-16-8 |
| PubChem ID | 16398939 |
| InChI Key | TXJZRSRTYPUYRW-YMXDCFFPSA-N |
| Smiles | COC([C@H]1CC2=C([C@H](C3=CC=C(C(OC)=O)C=C3)N1C(CCl)=O)NC4=CC=CC=C24)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 1S,3R-RSL3
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.09 | 100 |
Preparing Stock Solutions for 1S,3R-RSL3
The following data is based on the product molecular weight 440.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.27 mL | 11.34 mL | 22.68 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.27 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
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Product Datasheets for 1S,3R-RSL3
References for 1S,3R-RSL3
References are publications that support the biological activity of the product.
Yang et al (2014) Regulation of ferroptotic cancer cell death by GPX4. Cell. 156 317 PMID: 24439385
Yang et al (2016) Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc.Natl.Acad.Sci.U.S.A. 113 E4966 PMID: 27506793
Feng & Stockwell et al (2018) Unsolved mysteries: How does lipid peroxidation cause ferroptosis? PLoS. Biol. 16 e2006203 PMID: 29795546
If you know of a relevant reference for 1S,3R-RSL3, please let us know.
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Keywords: 1S,3R-RSL3, 1S,3R-RSL3 supplier, Ferroptosis, activator, activates, glutathione, peroxidase, 4, GPX4, inhibitors, inhibits, Other, Reductase, 6118, Tocris Bioscience
1 Citation for 1S,3R-RSL3
Citations are publications that use Tocris products. Selected citations for 1S,3R-RSL3 include:
Bi et al (2019) Metadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death Dis 10 682 PMID: 31527591
Do you know of a great paper that uses 1S,3R-RSL3 from Tocris? Please let us know.
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