Pricing Availability   Qty
Cat.No. 6118 - 1S,3R-RSL3 | C23H21ClN2O5 | CAS No. 1219810-16-8
Description: Induces ferroptosis; inhibits glutathione peroxidase 4 (GPX4)
Chemical Name: (1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate
Purity: ≥98% (HPLC)
Citations (1)
Literature (5)
Pathways (1)

Biological Activity for 1S,3R-RSL3

1S,3R-RSL3 is a glutathione peroxidase 4 (GPX4) inhibitor. Induces ferroptosis. Increases lipid peroxidase levels in vitro. Inhibits tumor formation and progression in vivo.

Licensing Information

Sold with the permission of Columbia University.

Technical Data for 1S,3R-RSL3

M. Wt 440.88
Formula C23H21ClN2O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1219810-16-8
PubChem ID 16398939
Smiles COC([C@H]1CC2=C([C@H](C3=CC=C(C(OC)=O)C=C3)N1C(CCl)=O)NC4=CC=CC=C24)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 1S,3R-RSL3

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 44.09 100

Preparing Stock Solutions for 1S,3R-RSL3

The following data is based on the product molecular weight 440.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.34 mL 22.68 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.13 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for 1S,3R-RSL3

Certificate of Analysis / Product Datasheet
Select another batch:

References for 1S,3R-RSL3

References are publications that support the biological activity of the product.

Yang et al (2014) Regulation of ferroptotic cancer cell death by GPX4. Cell. 156 317 PMID: 24439385

Yang et al (2016) Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc.Natl.Acad.Sci.U.S.A. 113 E4966 PMID: 27506793

Feng & Stockwell et al (2018) Unsolved mysteries: How does lipid peroxidation cause ferroptosis? PLoS. Biol. 16 e2006203 PMID: 29795546

If you know of a relevant reference for 1S,3R-RSL3, please let us know.

View Related Products by Product Action

View all Ferroptosis Activators

Keywords: 1S,3R-RSL3, 1S,3R-RSL3 supplier, Ferroptosis, activator, activates, glutathione, peroxidase, 4, GPX4, inhibitors, inhibits, Other, Reductase, 6118, Tocris Bioscience

1 Citation for 1S,3R-RSL3

Citations are publications that use Tocris products. Selected citations for 1S,3R-RSL3 include:

Bi et al (2019) Metadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death Dis 10 682 PMID: 31527591

Do you know of a great paper that uses 1S,3R-RSL3 from Tocris? Please let us know.

Reviews for 1S,3R-RSL3

There are currently no reviews for this product. Be the first to review 1S,3R-RSL3 and earn rewards!

Have you used 1S,3R-RSL3?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.


Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.


Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Pathways for 1S,3R-RSL3


MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.