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Novel RXR:PPARγ agonist; sensitizes PPARγ by enhancing its ligand binding activity. Also activates RXR:RAR and RXR:PPARα heterodimers in cotransfection assays. Displays selectivity over other permissive heterodimers such as RXR:LXRα and RXR:BAR/FXR. Exhibits antidiabetic properties in vivo.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Cesario et al (2001) The retinoid LG100754 is a novel RXR:PPARγ agonist and decreases glucose levels in vivo. Mol.Endocrinol. 15 1360 PMID: 11463859
Forman (2002) The antidiabetic agent LG100754 sensitizes cells to low concentrations of peroxisome proliferator-activated receptor γ ligands. J.Biol.Chem. 277 12503 PMID: 11877384
Germain et al (2006) International union of pharmacology LXIII. Retinoid X receptors. Pharmacol.Rev. 58 760 PMID: 17132853
Sato et al (2010) The "Phantom Effect" of the rexinoid LG100754: structural and functional insights. PLoS One 5 e15119 PMID: 21152046
Keywords: LG 100754, LG 100754 supplier, LG100754, selective, retinoid, x, receptors, RXR, nuclear, ppar, peroxisome, proliferator, activated, PPARgamma, PPARg, PPARγ, agonists, sensitizers, Retinoid, X, Receptor, Receptors, 3831, Tocris Bioscience
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