LG 100754

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Cat.No. 3831 - LG 100754 | C26H36O3 | CAS No. 180713-37-5
Description: RXR:PPAR agonist
Chemical Name: (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Novel RXR:PPARγ agonist; sensitizes PPARγ by enhancing its ligand binding activity. Also activates RXR:RAR and RXR:PPARα heterodimers in cotransfection assays. Displays selectivity over other permissive heterodimers such as RXR:LXRα and RXR:BAR/FXR. Exhibits antidiabetic properties in vivo.

Technical Data

M. Wt 396.56
Formula C26H36O3
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 180713-37-5
PubChem ID 6442223
InChI Key HNODNXQAYXJFMQ-LQUSFLDPSA-N
Smiles CC1(C)C2=C(C=C(OCCC)C(/C(C)=C\C=C\C(C)=C\C(O)=O)=C2)C(C)(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.66 100
ethanol 19.83 50

Preparing Stock Solutions

The following data is based on the product molecular weight 396.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.61 mL 25.22 mL
5 mM 0.5 mL 2.52 mL 5.04 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References

References are publications that support the biological activity of the product.

Cesario et al (2001) The retinoid LG100754 is a novel RXR:PPARγ agonist and decreases glucose levels in vivo. Mol.Endocrinol. 15 1360 PMID: 11463859

Forman (2002) The antidiabetic agent LG100754 sensitizes cells to low concentrations of peroxisome proliferator-activated receptor γ ligands. J.Biol.Chem. 277 12503 PMID: 11877384

Germain et al (2006) International union of pharmacology LXIII. Retinoid X receptors. Pharmacol.Rev. 58 760 PMID: 17132853

Sato et al (2010) The "Phantom Effect" of the rexinoid LG100754: structural and functional insights. PLoS One 5 e15119 PMID: 21152046


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Keywords: LG 100754, LG 100754 supplier, LG100754, selective, retinoid, x, receptors, RXR, nuclear, ppar, peroxisome, proliferator, activated, PPARgamma, PPARg, PPARγ, agonists, sensitizers, Retinoid, X, Receptor, Receptors, 3831, Tocris Bioscience

Citations for LG 100754

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