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Description: Photocrosslinker for hydrogels
Alternative Names: Lithium Phenyl(2,4,6-trimethylbenzoyl)phosphinate,Lithium PTMB phosphinate
Chemical Name: P-Phenyl-P-(2,4,6-trimethylbenzoyl)phosphinic acid
Purity: ≥98% (HPLC)
Citations (3)

Biological Activity for LAP

LAP is a photocrosslinker for hydrogels.

Technical Data for LAP

M. Wt 294.21
Formula C16H16LiO3P
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 85073-19-4
PubChem ID 68384915
Smiles CC1=C(C(P(C2=CC=CC=C2)(O[Li])=O)=O)C(C)=CC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LAP

Solvent Max Conc. mg/mL Max Conc. mM
water 29.42 100
DMSO 14.71 50

Preparing Stock Solutions for LAP

The following data is based on the product molecular weight 294.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.4 mL 16.99 mL 33.99 mL
5 mM 0.68 mL 3.4 mL 6.8 mL
10 mM 0.34 mL 1.7 mL 3.4 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets for LAP

Certificate of Analysis / Product Datasheet
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References for LAP

References are publications that support the biological activity of the product.

Fairbanks et al (2009) Photoinitiated polymerization of PEG-diacrylate with Li phenyl-2,4,6-trimethylbenzoylphosphinate: polymerization rate and cytocompatibility. Biomaterials 30 6702 PMID: 19783300

Valkevich et al (2012) Forging isopeptide bonds using thiol-ene chemistry: site-specific coupling of ubiquitin molecules for studying the activity of isopeptidases J.Am.Chem.Soc. 134 6916 PMID: 22497214

If you know of a relevant reference for LAP, please let us know.

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Keywords: LAP, LAP supplier, Photocrosslinkers, hydrogels, Lithium, Phenyl(2,4,6-trimethylbenzoyl)phosphinate, PTMB, phosphinate, Biochemicals, and, Molecular, Biology, 6146, Tocris Bioscience

3 Citations for LAP

Citations are publications that use Tocris products. Selected citations for LAP include:

Christophe et al (2021) An Intrinsically-Adhesive Family of Injectable and Photo-Curable Hydrogels with Functional Physicochemical Performance for Regenerative Medicine. Macromol Rapid Commun 42 e2000660 PMID: 33834552

Godfrey L et al (2022) Conventional rigid 2D substrates cause complex contractile signals in monolayers of human induced pluripotent stem cell-derived cardiomyocytes. J Physiol 600 483-507 PMID: 34761809

Steven M et al (2022) Sustained released of bioactive mesenchymal stromal cell-derived extracellular vesicles from 3D-printed gelatin methacrylate hydrogels. J Biomed Mater Res A 110 1190-1198 PMID: 35080115

Do you know of a great paper that uses LAP from Tocris? Please let us know.

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