L803-mts

Discontinued Product

Unfortunately L803-mts (Cat. No. 2256) has been withdrawn from sale for commercial reasons.
Cat.No. 2256 - L803-mts | Myr-Gly-Lys-Glu-Ala-Pro-Pro-Ala-Pro-Pro-Gln-pSer-Pro-NH2 | CAS No. 1043881-55-5
Description: Selective inhibitor of GSK-3
Datasheet
Citations (1)
Literature

Biological Activity

Selective peptide inhibitor of glycogen synthase kinase-3 (GSK-3). Produces antidepressive behavior in mice when administered in vivo. Shows no inhibition of PKC, PKB or cdc2 protein kinase. Exhibits insulin mimetic activity. Activates glycogen synthase activity 2.5-fold in HEK293 cells.

Licensing Information

Sold under licence from Tel Aviv University Future Technology LP.

Technical Data

M. Wt 1464.64
Formula C66H110N15O20P
Sequence GKEAPPAPPQSP

(Modifications: Gly-1 = Myr-Gly, Pro-12 = C-terminal amide, Ser-11 = pSer)

Storage Store at -20°C
CAS Number 1043881-55-5
Smiles CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](COP(O)(O)=O)C(=O)N1CCC[C@H]1C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 1464.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.68 mL 3.41 mL 6.83 mL
5 mM 0.14 mL 0.68 mL 1.37 mL
10 mM 0.07 mL 0.34 mL 0.68 mL
50 mM 0.01 mL 0.07 mL 0.14 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Chen et al (2004) Glycogen syntase kinase 3β (GSK3β) mediates 6-hydroxydopamine-induced neuronal death. FASEB J. 18 1162 PMID: 15132987

Kaidanovich-Beilin et al (2004) Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effects on β-catenin in mouse hippocampus. Biol.Psychiatry 55 781 PMID: 15050857

Plotkin et al (2003) Insulin mimetic action of synthetic phosphorylated peptide inhibitiors of glycogen synthase kinase-3. J.Pharm.Exp.Ther. 305 974 PMID:

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Keywords: L803-mts, supplier, L803-mts, peptides, inhibitors, glycogen, synthase, kinase-3, GSK-3, GSK3, inhibits, myristotylated, Glycogen, Synthase, Kinase, 3, Glycogen, Synthase, Kinase, Glycogen, Synthase, Kinase, 3, Tocris Bioscience

1 Citation for L803-mts

Citations are publications that use Tocris products. Selected citations for L803-mts include:

Hill et al (2015) Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter. Int J Obes (Lond) 45 1103 PMID: 25627813


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Pathways for L803-mts

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