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Biological Activity for L803-mts
Selective peptide inhibitor of glycogen synthase kinase-3 (GSK-3). Produces antidepressive behavior in mice when administered in vivo. Shows no inhibition of PKC, PKB or cdc2 protein kinase. Exhibits insulin mimetic activity. Activates glycogen synthase activity 2.5-fold in HEK293 cells.
Sold under licence from Tel Aviv University Future Technology LP.
Technical Data for L803-mts
(Modifications: Gly-1 = Myr-Gly, Pro-12 = C-terminal amide, Ser-11 = pSer)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for L803-mts
References are publications that support the biological activity of the product.
Chen et al (2004) Glycogen syntase kinase 3β (GSK3β) mediates 6-hydroxyDA-induced neuronal death. FASEB J. 18 1162 PMID: 15132987
Kaidanovich-Beilin et al (2004) Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effects on β-catenin in mouse hippocampus. Biol.Psychiatry 55 781 PMID: 15050857
Plotkin et al (2003) Ins mimetic action of synthetic phosphorylated peptide inhibitiors of glycogen synthase kinase-3. J.Pharm.Exp.Ther. 305 974
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Keywords: L803-mts, L803-mts supplier, L803-mts, peptides, inhibitors, glycogen, synthase, kinase-3, GSK-3, GSK3, inhibits, myristotylated, Glycogen, Synthase, Kinase, 3, 2256, Tocris Bioscience
1 Citation for L803-mts
Citations are publications that use Tocris products. Selected citations for L803-mts include:
Hill et al (2015) Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter. Int J Obes (Lond) 45 1103 PMID: 25627813
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.