Discontinued ProductUnfortunately L803-mts (Cat. No. 2256) has been withdrawn from sale for commercial reasons.
Selective peptide inhibitor of glycogen synthase kinase-3 (GSK-3). Produces antidepressive behavior in mice when administered in vivo. Shows no inhibition of PKC, PKB or cdc2 protein kinase. Exhibits insulin mimetic activity. Activates glycogen synthase activity 2.5-fold in HEK293 cells.
Sold under licence from Tel Aviv University Future Technology LP.
(Modifications: Gly-1 = Myr-Gly, Pro-12 = C-terminal amide, Ser-11 = pSer)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 1464.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.68 mL||3.41 mL||6.83 mL|
|5 mM||0.14 mL||0.68 mL||1.37 mL|
|10 mM||0.07 mL||0.34 mL||0.68 mL|
|50 mM||0.01 mL||0.07 mL||0.14 mL|
References are publications that support the products' biological activity.
Chen et al (2004) Glycogen syntase kinase 3β (GSK3β) mediates 6-hydroxydopamine-induced neuronal death. FASEB J. 18 1162 PMID: 15132987
Kaidanovich-Beilin et al (2004) Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effects on β-catenin in mouse hippocampus. Biol.Psychiatry 55 781 PMID: 15050857
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Keywords: L803-mts, supplier, L803-mts, peptides, inhibitors, glycogen, synthase, kinase-3, GSK-3, GSK3, inhibits, myristotylated, Glycogen, Synthase, Kinase, 3, Glycogen, Synthase, Kinase, Glycogen, Synthase, Kinase, 3, Tocris Bioscience
1 Citation for L803-mts
Citations are publications that use Tocris products. Selected citations for L803-mts include:
Hill et al (2015) Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter. Int J Obes (Lond) 45 1103 PMID: 25627813
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.