Discontinued Product

L803-mts (Cat. No. 2256) has been withdrawn from sale for commercial reasons.
Description: Selective inhibitor of GSK-3
Citations (1)
Literature (4)
Pathways (1)

Biological Activity for L803-mts

Selective peptide inhibitor of glycogen synthase kinase-3 (GSK-3). Produces antidepressive behavior in mice when administered in vivo. Shows no inhibition of PKC, PKB or cdc2 protein kinase. Exhibits insulin mimetic activity. Activates glycogen synthase activity 2.5-fold in HEK293 cells.

Licensing Information

Sold under licence from Tel Aviv University Future Technology LP.

Technical Data for L803-mts

M. Wt 1464.64
Formula C66H110N15O20P

(Modifications: Gly-1 = Myr-Gly, Pro-12 = C-terminal amide, Ser-11 = pSer)

Storage Store at -20°C
CAS Number 1043881-55-5
Smiles CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](COP(O)(O)=O)C(=O)N1CCC[C@H]1C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for L803-mts

References are publications that support the biological activity of the product.

Chen et al (2004) Glycogen syntase kinase 3β (GSK3β) mediates 6-hydroxyDA-induced neuronal death. FASEB J. 18 1162 PMID: 15132987

Kaidanovich-Beilin et al (2004) Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effects on β-catenin in mouse hippocampus. Biol.Psychiatry 55 781 PMID: 15050857

Plotkin et al (2003) Ins mimetic action of synthetic phosphorylated peptide inhibitiors of glycogen synthase kinase-3. J.Pharm.Exp.Ther. 305 974

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Keywords: L803-mts, L803-mts supplier, L803-mts, peptides, inhibitors, glycogen, synthase, kinase-3, GSK-3, GSK3, inhibits, myristotylated, Glycogen, Synthase, Kinase, 3, 2256, Tocris Bioscience

1 Citation for L803-mts

Citations are publications that use Tocris products. Selected citations for L803-mts include:

Hill et al (2015) Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter. Int J Obes (Lond) 45 1103 PMID: 25627813

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Stem Cell Research Product Guide

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Stem Cells Scientific Review

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Pathways for L803-mts

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.