Discontinued ProductUnfortunately L803-mts (Cat. No. 2256) has been withdrawn from sale for commercial reasons.
Selective peptide inhibitor of glycogen synthase kinase-3 (GSK-3). Produces antidepressive behavior in mice when administered in vivo. Shows no inhibition of PKC, PKB or cdc2 protein kinase. Exhibits insulin mimetic activity. Activates glycogen synthase activity 2.5-fold in HEK293 cells. Myristoylated version of L803 (Cat. No. 2235).
Sold under licence from Tel Aviv University Future Technology LP.
(Modifications: Gly-1 = Myr-Gly, Pro-12 = C-terminal amide, Ser-11 = pSer)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 1464.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.68 mL||3.41 mL||6.83 mL|
|5 mM||0.14 mL||0.68 mL||1.37 mL|
|10 mM||0.07 mL||0.34 mL||0.68 mL|
|50 mM||0.01 mL||0.07 mL||0.14 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Chen et al (2004) Glycogen syntase kinase 3β (GSK3β) mediates 6-hydroxydopamine-induced neuronal death. FASEB J. 18 1162 PMID: 15132987
Kaidanovich-Beilin et al (2004) Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effects on β-catenin in mouse hippocampus. Biol.Psychiatry 55 781 PMID: 15050857
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Keywords: L803-mts peptides inhibitors glycogen synthase kinase-3 GSK-3 GSK3 inhibits myristotylated Glycogen Synthase Kinase 3
1 Citation for L803-mts
Citations are publications that use Tocris products. Selected citations for L803-mts include:
Hill et al (2015) Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter. Int J Obes (Lond) 45 1103 PMID: 25627813
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