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L Moses dihydrochloride
Biological Activity for L Moses dihydrochloride
L Moses dihydrochloride is a high affinity and selective cell-permeable p300/CBP-associated factor (PCAF) inhibitor (Ki = 47 nM), which exhibits no significant activity against a panel of 48 other bromodomains except GCN5 (Kd = 600 nM). L Moses exhibits >4500-fold selectivity for PCAF over BRD4. The compound inhibits Tunicamycin (Cat. No. 3516) -induced neuronal cell death by reversing the transcriptional changes associated with Tunicamycin treatment. L Moses exhibits metabolic stability in mouse and human liver microsomes and no observable cytotoxicity in peripheral blood mononuclear cells (PBMC).
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the L-Moses probe summary on the SGC website.
External Portal Information for L Moses dihydrochloride
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of L-Moses is reviewed on the chemical probes website.
Compound Libraries for L Moses dihydrochloride
Technical Data for L Moses dihydrochloride
|Desiccate at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for L Moses dihydrochloride
|Max Conc. mg/mL
|Max Conc. mM
Preparing Stock Solutions for L Moses dihydrochloride
The following data is based on the product molecular weight 433.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass
Product Datasheets for L Moses dihydrochloride
References for L Moses dihydrochloride
References are publications that support the biological activity of the product.
Moustakim et al (2017) Discovery of a PCAF bromodomain chemical probe. Angew.Chem.Int.Ed. 56 827 PMID: 27966810
Pavlou et al (2023) CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death. Sci Rep 13 3934 PMID: 36894612
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1 Citation for L Moses dihydrochloride
Citations are publications that use Tocris products. Selected citations for L Moses dihydrochloride include:
Pavlou et al (2023) CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death. Sci.Rep. 13 3934 PMID: 36894612
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics in Cancer Poster
This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.