L-Azidohomoalanine hydrochloride

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Cat.No. 6584 - L-Azidohomoalanine hydrochloride | C4H8N4O2.HCl | CAS No. 942518-29-8
Description: Unnatural amino acid for bio-orthogonal labeling of newly synthesized proteins
Chemical Name: (S)-2-Amino-4-azidobutanoic acid hydrochloride
Datasheet
Citations
Reviews
Literature

Biological Activity

Unnatural amino acid. Incorporated into proteins during de novo protein synthesis, with no effect on protein degradation. Requires methionine-free medium for efficient incorporation. Substrate for wild-type methionyl-tRNA synthetase (MetRS) in vivo. Can be used in BONCAT (bio-orthogonal non-canonical amino acid tagging) for the identification of newly synthesized proteins.

Technical Data

M. Wt 180.59
Formula C4H8N4O2.HCl
Storage Store at -20°C
CAS Number 942518-29-8
PubChem ID 147480
InChI Key NNWQLZWAZSJGLY-VKHMYHEASA-N
Smiles N[C@H](C(O)=O)CCN=[N+]=[N-].Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 18.06 100

Preparing Stock Solutions

The following data is based on the product molecular weight 180.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.54 mL 27.69 mL 55.37 mL
5 mM 1.11 mL 5.54 mL 11.07 mL
10 mM 0.55 mL 2.77 mL 5.54 mL
50 mM 0.11 mL 0.55 mL 1.11 mL

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References

References are publications that support the biological activity of the product.

Dieterich et al (2006) Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT). Proc.Natl.Acad.Sci.U.S.A. 103 9482 PMID: 16769897

Lang & Chin et al (2014) Cellular incorporation of unnatural amino acids and bioorthogonal labeling of proteins. Chem.Rev. 114 4764 PMID: 24655057

Wang et al (2017) Nonradioactive quantification of autophagic protein degradation with L-azidohomoalanine labeling. Nat.Protoc. 12 279 PMID: 28079880


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Citations for L-Azidohomoalanine hydrochloride

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