Discontinued Product

L-690,488 (Cat. No. 0682) has been withdrawn from sale for commercial reasons.
Description: Cell permeable prodrug of the IMPase inhibitor L-690,330 (Cat. No. 0681)
Chemical Name: 1-[(4-Hydroxyphenoxy)ethylidene]bis[phosphinylidynebis(oxymethylene)]-2,2-dimethylpropanoate
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for L-690,488

L-690,488 is a cell-permeable prodrug of the potent inositol monophosphatase inhibitor L-690,330 (Cat. No. 0681); penetrates cells more effectively than its metabolite.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data for L-690,488

M. Wt 754.7
Formula C32H52O16P2
Storage Store at -80°C
Purity ≥98% (HPLC)
CAS Number 142523-14-6
PubChem ID 5132514
Smiles OC1=CC=C(OC(P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)(C)P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for L-690,488

Certificate of Analysis / Product Datasheet
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References for L-690,488

References are publications that support the biological activity of the product.

Atack et al (1994) Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers. J.Pharmacol.Exp.Ther. 270 70 PMID: 8035344

Chen et al (1998) Stimulatory effect of Li on glucose transport in rat adipocytes is not mediated by elevation of IP1. Am.J.Physiol. 275 E272 PMID: 9688629

Keywords: L-690,488, L-690,488 supplier, Inositol, monophosphatase, inhibitors, inhibits, PIP2, Lipids, Ins145P3, 5-Phosphatase, IMPase, Phosphatases, L690488, 0682, Tocris Bioscience

1 Citation for L-690,488

Citations are publications that use Tocris products. Selected citations for L-690,488 include:

Harding et al (2013) LtpD is a novel Legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1. Mol Cancer 81 4261 PMID: 24002062

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