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Cat.No. 0682 - L-690,488 | C32H52O16P2 | CAS No. 142523-14-6
Description: Cell permeable prodrug of the IMPase inhibitor L-690,330 (Cat. No. 0681)
Chemical Name: 1-[(4-Hydroxyphenoxy)ethylidene]bis[phosphinylidynebis(oxymethylene)]-2,2-dimethylpropanoate
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

Cell-permeable prodrug of the potent inositol monophosphatase inhibitor L-690,330 (Cat. No. 0681); penetrates cells more effectively than its metabolite.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

M. Wt 754.7
Formula C32H52O16P2
Storage Store at -80°C
Purity ≥98% (HPLC)
CAS Number 142523-14-6
PubChem ID 5132514
Smiles OC1=CC=C(OC(P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)(C)P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 75.47 100
ethanol 75.47 100

Preparing Stock Solutions

The following data is based on the product molecular weight 754.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.33 mL 6.63 mL 13.25 mL
5 mM 0.27 mL 1.33 mL 2.65 mL
10 mM 0.13 mL 0.66 mL 1.33 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Atack et al (1994) Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers. J.Pharmacol.Exp.Ther. 270 70 PMID: 8035344

Chen et al (1998) Stimulatory effect of lithium on glucose transport in rat adipocytes is not mediated by elevation of IP1. Am.J.Physiol. 275 E272 PMID: 9688629

If you know of a relevant reference for L-690,488, please let us know.

Keywords: L-690,488, supplier, Inositol, monophosphatase, inhibitors, inhibits, PIP2, Lipids, Ins145P3, 5-Phosphatase, IMPase, Phosphatases, L690488, Inositol, Lipids, Inositol, Phosphatases, Inositol, Phosphatases, Tocris Bioscience

1 Citation for L-690,488

Citations are publications that use Tocris products. Selected citations for L-690,488 include:

Harding et al (2013) LtpD is a novel Legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1. Mol Cancer 81 4261 PMID: 24002062

Do you know of a great paper that uses L-690,488 from Tocris? If so please let us know.

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