L 012 sodium salt

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Cat.No. 5085 - L 012 sodium salt | C13H8ClN4NaO2 | CAS No. 143556-24-5
Description: Chemiluminescent ROS and RNS indicator
Chemical Name: 8-Amino-5-chloro-2,3-dihydro-7-phenyl-pyrido[3,4-d]pyridazine sodium salt
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Luminal-based chemiluminescent probe. Detects NAPDH oxidase-derived reactive oxygen and nitrogen species (ROS and RNS). Active in vitro and in vivo.

Technical Data

M. Wt 310.67
Formula C13H8CIN4NaO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 143556-24-5
PubChem ID 78243715
Smiles NC1=C3C(C(O[Na])=NNC3=O)=C(Cl)N=C1C2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 6.21 20
DMSO 31.07 100

Preparing Stock Solutions

The following data is based on the product molecular weight 310.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.22 mL 16.09 mL 32.19 mL
5 mM 0.64 mL 3.22 mL 6.44 mL
10 mM 0.32 mL 1.61 mL 3.22 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Kielland et al (2009) In vivo imaging of reactive oxygen and nitrogen species in inflammation using the luminescent probe L-012. Free Radic.Biol.Med. 47 760 PMID: 19539751

Zhou et al (2012) Noninvasive assessment of localized inflammatory responses. Free Radic.Biol.Med. 52 218 PMID: 22080048

Ichibangase et al (2013) Evaluation of lophine derivatives as L-012 (luminol analog)-dependent chemiluminescence enhancers for measuring horseradish peroxidase and H2 O2. Luminescence. 29 118 PMID: 23630098

If you know of a relevant reference for L 012 sodium salt, please let us know.

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