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Self-assembling peptide that forms a hydrogel matrix to support growth of cells in the presence of an ionic solution. Enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs).
(Modifications: Lys-1 = N-terminal Ac, Leu-12 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 0.50 mg/ml in water|
References are publications that support the biological activity of the product.
Kisiday et al (2002) Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proc.Natl.Acad.Sci.U.S.A. 99 9996 PMID: 12119393
Tripathi et al (2015) Variants of self-assembling peptide, KLD-12 that show both rapid fracture healing and antimicrobial properties. Biomaterials. 56 92 PMID: 25934283
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Keywords: KLD 12, KLD 12 supplier, KLD12, peptide, hydrogel, matrix, self, assembly, stem, cell, growth, Stem, Cell, Proliferation, 6797, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.