Selective agonist at kainate receptors. Potent excitant and neurotoxin. Also available as part of the Kainate Receptor Tocriset™.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||5.33||25 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 213.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.69 mL||23.45 mL||46.9 mL|
|5 mM||0.94 mL||4.69 mL||9.38 mL|
|10 mM||0.47 mL||2.34 mL||4.69 mL|
|50 mM||0.09 mL||0.47 mL||0.94 mL|
References are publications that support the biological activity of the product.
Watkins and Evans (1981) Excitatory amino acid transmitters. Annu.Rev.Pharmacol.Toxicol. 21 165 PMID: 6112965
Watkins (1978) Excitatory amino acids. Kainic acid as a Tool in Neurobiology. Edited by E 37
If you know of a relevant reference for Kainic acid, please let us know.
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Keywords: Kainic acid, Kainic acid supplier, Potent, excitant, neurotoxin, Glutamate, Kainate, Receptors, iGluR, Ionotropic, 0222, Tocris Bioscience
30 Citations for Kainic acid
Citations are publications that use Tocris products. Selected citations for Kainic acid include:
Chang et al (2014) Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid. Neurobiol Dis 62 296 PMID: 24148856
Shin et al (2008) Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsy. Neurobiol Dis 32 26 PMID: 18657617
Evans (2017) Assembly, secretory pathway trafficking, and surface delivery of kainate receptors is regulated by neuronal activity. Cell Rep 19 2613 PMID: 28636947
Zhao (2017) Signaling by growth/differentiation factor 5 through the bone morphogenetic protein receptortype IB protects neurons against kainic acid-induced neurodegeneration. Neurosci Lett 651 36 PMID: 28458020
Fletcher (2017) Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy. Nat Neurosci 20 905 PMID: 28504671
Ferando and Mody (2015) In vitro gamma oscillations following partial and complete ablation of δ subunit-containing GABAA receptors from parvalbumin interneurons. Neuropharmacology 88 91 PMID: 25261782
Bernard et al (2013) Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures. Nat Commun 59 42736 PMID: 23831253
Krook-Magnuson et al (2013) On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy. J Neurosci 4 1376 PMID: 23340416
Marrocco et al (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. Proc Natl Acad Sci U S A 32 17143 PMID: 23197707
Wang and Green (2011) Functional role of neurotrophin-3 in synapse regeneration by spiral ganglion neurons on inner hair cells after excitotoxic trauma in vitro. J Neurosci 31 7938 PMID: 21613508
Doyon et al (2011) Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis. J Neurosci 7 e1002149 PMID: 21931544
Milstein et al (2007) TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating. Neuron 55 905 PMID: 17880894
Horita et al (2012) Specialized motor-driven dusp1 expression in the song systems of multiple lineages of vocal learning birds. PLoS One 7 e42173 PMID: 22876306
Huang et al (2012) Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds. PLoS One 7 e30662 PMID: 22292013
Rodriguez-Diaz et al (2012) Real-time detection of acetylcholine release from the human endocrine pancreas. Nat Protoc 7 1015 PMID: 22555241
Hitt et al (2010) BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization. Mol Neurodegener 5 31 PMID: 20731874
Peng et al (2010) Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling. J Neurosci 30 16220 PMID: 21123568
Park et al (2016) Involvement of AMPA Receptor and Its Flip and Flop Isoforms in Retinal Ganglion Cell Death Following Oxygen/Glucose Deprivation. Invest Ophthalmol Vis Sci 57 508 PMID: 26868754
Elliott-Hunt et al (2004) Galanin acts as a neuroprotective factor to the hippocampus. PLoS Comput Biol 101 5105 PMID: 15041741
Szokol et al (2015) Augmentation of Ca(2+) signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy. J Biol Chem 9 49 PMID: 25762896
Xiao et al (2015) CX3 chemokine receptor 1 deficiency leads to reduced dendritic complexity and delayed maturation of newborn neurons in the adult mouse hippocampus. Front Cell Neurosci 10 772 PMID: 26109952
Spampinato et al (2015) Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes. Neurotox Res 8 462 PMID: 25642169
Parrish et al (2015) Methionine increases BDNF DNA methylation and improves memory in epilepsy. Neurobiol Dis 2 401 PMID: 25909085
Hou and Yu (2013) Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4. Neural Regen Res 288 2501 PMID: 23233668
Chuang et al (2012) Peroxisome proliferator-activated receptors γ/mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus. J Neuroinflammation 9 184 PMID: 22849356
Domin et al (2014) Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo. Ann Clin Transl Neurol 26 99 PMID: 24402869
Fritsch et al (2009) Pathological alterations in GABAergic interneurons and reduced tonic inhibition in the basolateral amygdala during epileptogenesis. Neuroscience 163 415 PMID: 19540312
Neves et al (2013) The LIM homeodomain protein Lhx6 regulates maturation of interneurons and network excitability in the mammalian cortex. Cereb Cortex 23 1811 PMID: 22710612
Ferando and Mody (2013) Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons. Front Neural Circuits 7 144 PMID: 24062647
deCarvalho et al (2013) Aversive cues fail to activate fos expression in the asymmetric olfactory-habenula pathway of zebrafish. Front Neural Circuits 7 98 PMID: 23734103
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Learning & Memory Poster
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