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Kainic acid (synthetic)
Biological Activity for Kainic acid (synthetic)
Kainic acid, also known as kainate, is a selective agonist of kainate ionotropic glutamate receptors (EC50 = 0.6 μM - 7.4 μM) and a partial agonist at AMPA receptors (EC50 = 31 μM - 170 μM). Kainic acid is used to model epilepsy in vivo and to study the mechanisms of neurodegeneration and neurocytosis induced by excess stimulation by kainic acid. Kainate is shown to be involved in amyloidogenic processing of amyloid precursor protein and Aβ peptides in Alzheimer's. Synthetic version of Kainic acid (Cat. No. 0222)
Technical Data for Kainic acid (synthetic)
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Kainic acid (synthetic)
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Kainic acid (synthetic)
The following data is based on the product molecular weight 213.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||18.76 mL||93.8 mL||187.59 mL|
|1.25 mM||3.75 mL||18.76 mL||37.52 mL|
|2.5 mM||1.88 mL||9.38 mL||18.76 mL|
|12.5 mM||0.38 mL||1.88 mL||3.75 mL|
Product Datasheets for Kainic acid (synthetic)
References for Kainic acid (synthetic)
References are publications that support the biological activity of the product.
Watkins & Evans (1981) Excitatory amino acid transmitters. Annu.Rev.Pharmacol.Toxicol. 21 165 PMID: 6112965
Watkins (1978) Excitatory amino acids. Kainic acid as a Tool in Neurobiology. Edited by E
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Citations for Kainic acid (synthetic)
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.