Kainic acid (synthetic)

Pricing Availability   Qty
Description: Kainate agonist; excitant and neurotoxin
Chemical Name: (2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for Kainic acid (synthetic)

Kainic acid, also known as kainate, is a selective agonist of kainate ionotropic glutamate receptors (EC50 = 0.6 μM - 7.4 μM) and a partial agonist at AMPA receptors (EC50 = 31 μM - 170 μM). Kainic acid is used to model epilepsy in vivo and to study the mechanisms of neurodegeneration and neurocytosis induced by excess stimulation by kainic acid. Kainate is shown to be involved in amyloidogenic processing of amyloid precursor protein and Aβ peptides in Alzheimer's. Synthetic version of Kainic acid (Cat. No. 0222)

Related compounds include the kainate receptor agonist Domoic acid (Cat. No. 0269) and the antagonist NBQX (Cat. No. 0373).

Technical Data for Kainic acid (synthetic)

M. Wt 213.23
Formula C10H15NO4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 487-79-6
PubChem ID 10255
InChI Key VLSMHEGGTFMBBZ-OOZYFLPDSA-N
Smiles C=C(C)[C@@H]1[C@H](CC(O)=O)[C@@H](C(O)=O)NC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Kainic acid (synthetic)

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 5.33 25

Preparing Stock Solutions for Kainic acid (synthetic)

The following data is based on the product molecular weight 213.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 18.76 mL 93.8 mL 187.59 mL
1.25 mM 3.75 mL 18.76 mL 37.52 mL
2.5 mM 1.88 mL 9.38 mL 18.76 mL
12.5 mM 0.38 mL 1.88 mL 3.75 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Kainic acid (synthetic)

Certificate of Analysis / Product Datasheet
Select another batch:

References for Kainic acid (synthetic)

References are publications that support the biological activity of the product.

Watkins & Evans (1981) Excitatory amino acid transmitters. Annu.Rev.Pharmacol.Toxicol. 21 165 PMID: 6112965

Watkins (1978) Excitatory amino acids. Kainic acid as a Tool in Neurobiology. Edited by E


If you know of a relevant reference for Kainic acid (synthetic), please let us know.

View Related Products by Target

View Related Products by Product Action

View all Kainate Receptor Agonists

Keywords: Kainic acid (synthetic), Kainic acid (synthetic) supplier, Potent, excitant, neurotoxin, Glutamate, Kainate, Receptors, iGluR, Ionotropic, synthetic, KA, 7065, Tocris Bioscience

Citations for Kainic acid (synthetic)

Citations are publications that use Tocris products.

Currently there are no citations for Kainic acid (synthetic). Do you know of a great paper that uses Kainic acid (synthetic) from Tocris? Please let us know.

Reviews for Kainic acid (synthetic)

There are currently no reviews for this product. Be the first to review Kainic acid (synthetic) and earn rewards!

Have you used Kainic acid (synthetic)?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.