Kainic acid (synthetic)

Pricing Availability   Qty
Description: Kainate agonist; excitant and neurotoxin
Chemical Name: (2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for Kainic acid (synthetic)

Kainic acid, also known as kainate, is a selective agonist of kainate ionotropic glutamate receptors (EC50 = 0.6 μM - 7.4 μM) and a partial agonist at AMPA receptors (EC50 = 31 μM - 170 μM). Kainic acid is used to model epilepsy in vivo and to study the mechanisms of neurodegeneration and neurocytosis induced by excess stimulation by kainic acid. Kainate is shown to be involved in amyloidogenic processing of amyloid precursor protein and Aβ peptides in Alzheimer's. Synthetic version of Kainic acid (Cat. No. 0222)

Related compounds include the kainate receptor agonist Domoic acid (Cat. No. 0269) and the antagonist NBQX (Cat. No. 0373).

Technical Data for Kainic acid (synthetic)

M. Wt 213.23
Formula C10H15NO4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 487-79-6
PubChem ID 10255
Smiles C=C(C)[C@@H]1[C@H](CC(O)=O)[C@@H](C(O)=O)NC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Kainic acid (synthetic)

Solvent Max Conc. mg/mL Max Conc. mM
water 5.33 25

Preparing Stock Solutions for Kainic acid (synthetic)

The following data is based on the product molecular weight 213.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 18.76 mL 93.8 mL 187.59 mL
1.25 mM 3.75 mL 18.76 mL 37.52 mL
2.5 mM 1.88 mL 9.38 mL 18.76 mL
12.5 mM 0.38 mL 1.88 mL 3.75 mL

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Product Datasheets for Kainic acid (synthetic)

Certificate of Analysis / Product Datasheet
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References for Kainic acid (synthetic)

References are publications that support the biological activity of the product.

Watkins & Evans (1981) Excitatory amino acid transmitters. Annu.Rev.Pharmacol.Toxicol. 21 165 PMID: 6112965

Watkins (1978) Excitatory amino acids. Kainic acid as a Tool in Neurobiology. Edited by E

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Keywords: Kainic acid (synthetic), Kainic acid (synthetic) supplier, Potent, excitant, neurotoxin, Glutamate, Kainate, Receptors, iGluR, Ionotropic, synthetic, KA, 7065, Tocris Bioscience

Citations for Kainic acid (synthetic)

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