Domoic acid

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Cat.No. 0269 - Domoic acid | C15H21NO6 | CAS No. 14277-97-5
Description: Potent and selective kainate agonist
Chemical Name: (2S,3S,4R,5'R)-2-Carboxy-4-(5'-carboxy-1'-methyl-1Z,3E-hexadienyl)-3-pyrrolidineacetic acid
Purity: ≥95% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Kainate receptor agonist. More potent and possibly more selective than kainate at kainate receptors, as demonstrated in electrophysiological studies.

Technical Data

M. Wt 311.33
Formula C15H21NO6
Storage Desiccate at -20°C
Purity ≥95% (HPLC)
CAS Number 14277-97-5
PubChem ID 5282253
InChI Key VZFRNCSOCOPNDB-AOKDLOFSSA-N
Smiles [H][C@](C)([C@](O)=O)/C=C/C=[C@@](C)\[C@H]1CN[C@H]([C@@](O)=O)[C@H]1CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 50 mM in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Agrawal and Evans (1986) The primary afferent depolarizing action of kainate in the rat. Br.J.Pharmacol. 87 345 PMID: 3513882

Debonnel et al (1989) Domoic acid, the alleged 'mussel toxin', might produce its neurotoxic effect through kainate receptor activation: an electro-physiological study in rat dorsal hippocampus. Can.J.Physiol.Pharmacol. 67 29 PMID: 2540893

Watkins et al (1990) Experiments with kainate and quisqualate agonists and antagonists in relation to the sub-classification of 'non-NMDA' receptors. Excitatory Amino Acids and Synaptic Plasticity. Ed 49

Hampson and Manalo (1998) The activation of glutamate receptors by kainic acid and domoic acid. Nat.Toxins 6 153 PMID: 10223631


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Keywords: Domoic acid, Domoic acid supplier, Potent, selective, kainate, agonists, Glutamate, Kainate, Receptors, iGluR, Ionotropic, 0269, Tocris Bioscience

1 Citation for Domoic acid

Citations are publications that use Tocris products. Selected citations for Domoic acid include:

Rojas et al (2013) Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors. Mol Pharmacol 83 106 PMID: 23066089


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