Domoic acid

Discontinued Product

Domoic acid (Cat. No. 0269) has been withdrawn from sale for commercial reasons.
Description: Potent and selective kainate agonist
Chemical Name: (2S,3S,4R,5'R)-2-Carboxy-4-(5'-carboxy-1'-methyl-1Z,3E-hexadienyl)-3-pyrrolidineacetic acid
Purity: ≥95% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity for Domoic acid

Domoic acid is a kainate receptor agonist. More potent and possibly more selective than kainate at kainate receptors, as demonstrated in electrophysiological studies.

Technical Data for Domoic acid

M. Wt 311.33
Formula C15H21NO6
Storage Desiccate at -20°C
Purity ≥95% (HPLC)
CAS Number 14277-97-5
PubChem ID 5282253
InChI Key VZFRNCSOCOPNDB-AOKDLOFSSA-N
Smiles [H][C@](C)([C@](O)=O)/C=C/C=[C@@](C)\[C@H]1CN[C@H]([C@@](O)=O)[C@H]1CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Domoic acid

Certificate of Analysis / Product Datasheet
Select another batch:

References for Domoic acid

References are publications that support the biological activity of the product.

Agrawal and Evans (1986) The primary afferent depolarizing action of kainate in the rat. Br.J.Pharmacol. 87 345 PMID: 3513882

Debonnel et al (1989) Domoic acid, the alleged 'mussel toxin', might produce its neurotoxic effect through kainate receptor activation: an electro-physiological study in rat dorsal hippocampus. Can.J.Physiol.Pharmacol. 67 29 PMID: 2540893

Watkins et al (1990) Experiments with kainate and quisqualate agonists and antagonists in relation to the sub-classification of 'non-NMDA' receptors. Excitatory Amino Acids and Synaptic Plasticity. Ed 49

Hampson and Manalo (1998) The activation of glutamate receptors by kainic acid and domoic acid. Nat.Toxins 6 153 PMID: 10223631

View Related Products by Target

View Related Products by Product Action

View all Kainate Receptor Agonists

Keywords: Domoic acid, Domoic acid supplier, Potent, selective, kainate, agonists, Glutamate, Kainate, Receptors, iGluR, Ionotropic, 0269, Tocris Bioscience

1 Citation for Domoic acid

Citations are publications that use Tocris products. Selected citations for Domoic acid include:

Rojas et al (2013) Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors. Mol Pharmacol 83 106 PMID: 23066089


Reviews for Domoic acid

There are currently no reviews for this product. Be the first to review Domoic acid and earn rewards!

Have you used Domoic acid?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.