Ellipticine

Pricing Availability Delivery Time Qty
Cat.No. 3357 - Ellipticine | C17H14N2 | CAS No. 519-23-3
Description: Antitumor and intercalating agent; inhibits DNA topoisomerase II
Chemical Name: 5,11-Dimethyl-6H-pyrido[4,3-b]carbazole
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Naturally occurring plant alkaloid with antitumor activity. DNA intercalating agent; blocks DNA topoisomerase II activity. Prevents p53 phosphorylation in lung cancer cells.

Technical Data

M. Wt 246.31
Formula C17H14N2
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 519-23-3
PubChem ID 3213
InChI Key CTSPAMFJBXKSOY-UHFFFAOYSA-N
Smiles CC1=C4C(C=CN=C4)=C(C)C3=C1C2=C(N3)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.32 50

Preparing Stock Solutions

The following data is based on the product molecular weight 246.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.06 mL 20.3 mL 40.6 mL
5 mM 0.81 mL 4.06 mL 8.12 mL
10 mM 0.41 mL 2.03 mL 4.06 mL
50 mM 0.08 mL 0.41 mL 0.81 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ohashi et al (1995) Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism. Jpn.J.Cancer Res. 86 819 PMID: 7591958

Tewey et al (1984) Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J.Biol.Chem. 259 9182 PMID: 6086625


If you know of a relevant reference for Ellipticine, please let us know.

View Related Products by Product Action

View all DNA Topoisomerase Inhibitors

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1 Citation for Ellipticine

Citations are publications that use Tocris products. Selected citations for Ellipticine include:

Kishikawa et al (2015) Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine. Oncotarget 6 8339 PMID: 25826076


Do you know of a great paper that uses Ellipticine from Tocris? If so please let us know.

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for Ellipticine

Protocols

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