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Naturally occurring plant alkaloid with antitumor activity. DNA intercalating agent; blocks DNA topoisomerase II activity. Prevents p53 phosphorylation in lung cancer cells.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 246.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||8.12 mL||40.6 mL||81.2 mL|
|2.5 mM||1.62 mL||8.12 mL||16.24 mL|
|5 mM||0.81 mL||4.06 mL||8.12 mL|
|25 mM||0.16 mL||0.81 mL||1.62 mL|
References are publications that support the biological activity of the product.
Ohashi et al (1995) Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism. Jpn.J.Cancer Res. 86 819 PMID: 7591958
Tewey et al (1984) Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J.Biol.Chem. 259 9182 PMID: 6086625
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2 Citations for Ellipticine
Citations are publications that use Tocris products. Selected citations for Ellipticine include:
Kishikawa et al (2015) Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine. Oncotarget 6 8339 PMID: 25826076
Hou et al (2016) IDA is a broad-spectrum enterovirus replication inhibitor that selectively targets the virus internal ribosomal entry site. J Gen Virol 97 1122 PMID: 26879094
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Reviews for Ellipticine
Average Rating: 5 (Based on 1 Review.)
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Ellipticine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.
Literature in this Area
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.