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Cat.No. 3357 - Ellipticine | C17H14N2 | CAS No. 519-23-3
Description: Antitumor and intercalating agent; inhibits DNA topoisomerase II
Chemical Name: 5,11-Dimethyl-6H-pyrido[4,3-b]carbazole
Purity: ≥97% (HPLC)
Citations (2)
Reviews (1)
Literature (2)

Biological Activity for Ellipticine

Ellipticine is a naturally occurring plant alkaloid with antitumor activity. DNA intercalating agent; blocks DNA topoisomerase II activity. Prevents p53 phosphorylation in lung cancer cells.

Technical Data for Ellipticine

M. Wt 246.31
Formula C17H14N2
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 519-23-3
PubChem ID 3213
Smiles CC1=C4C(C=CN=C4)=C(C)C3=C1C2=C(N3)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ellipticine

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 12.32 50

Preparing Stock Solutions for Ellipticine

The following data is based on the product molecular weight 246.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.12 mL 40.6 mL 81.2 mL
2.5 mM 1.62 mL 8.12 mL 16.24 mL
5 mM 0.81 mL 4.06 mL 8.12 mL
25 mM 0.16 mL 0.81 mL 1.62 mL

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References for Ellipticine

References are publications that support the biological activity of the product.

Ohashi et al (1995) Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism. Jpn.J.Cancer Res. 86 819 PMID: 7591958

Tewey et al (1984) Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J.Biol.Chem. 259 9182 PMID: 6086625

If you know of a relevant reference for Ellipticine, please let us know.

View Related Products by Product Action

View all DNA Topoisomerase Inhibitors

Keywords: Ellipticine, Ellipticine supplier, apoptosis, inducers, DNA, topoisomerase, II, inhibits, inhibitors, p53, phosphorylation, antitumor, intercalating, agents, plant, alkaloid, protein, kinase, CK2, Topoisomerase, DNA,, RNA, and, Protein, Synthesis, 3357, Tocris Bioscience

2 Citations for Ellipticine

Citations are publications that use Tocris products. Selected citations for Ellipticine include:

Kishikawa et al (2015) Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine. Oncotarget 6 8339 PMID: 25826076

Hou et al (2016) IDA is a broad-spectrum enterovirus replication inhibitor that selectively targets the virus internal ribosomal entry site. J Gen Virol 97 1122 PMID: 26879094

Do you know of a great paper that uses Ellipticine from Tocris? Please let us know.

Reviews for Ellipticine

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Ellipticine quickly kills melanoma cells in vitro.
By Anonymous on 02/14/2019
Assay Type: In Vitro
Species: Human

Ellipticine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.