JLK 6

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Cat.No. 2677 - JLK 6 | C10H8ClNO3 | CAS No. 62252-26-0
Description: Inhibitor of γ-secretase-mediated βAPP processing
Chemical Name: 7-Amino-4-chloro-3-methoxy-1H-2-benzopyran
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of γ-secretase that selectively inhibits βAPP cleavage without affecting other γ-secretase-mediated pathways. Prevents recovery of Aβ40 and Aβ42 from HEK293 cell overexpressing wild-type or Swedish-mutated βAPP (IC50 ~ 30 μM) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α-secretase, the proteosome or GSK3β.

Technical Data

M. Wt 225.63
Formula C10H8ClNO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 62252-26-0
PubChem ID 3803
InChI Key AMDGKLWVCUXONP-UHFFFAOYSA-N
Smiles COC1=C(Cl)C2=CC=C(N)C=C2C(=O)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.56 100
ethanol 5.64 25

Preparing Stock Solutions

The following data is based on the product molecular weight 225.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.43 mL 22.16 mL 44.32 mL
5 mM 0.89 mL 4.43 mL 8.86 mL
10 mM 0.44 mL 2.22 mL 4.43 mL
50 mM 0.09 mL 0.44 mL 0.89 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Petit et al (2001) New protease inhibitors prevent γ-secretase-mediated production of Aβ40/42 without affecting Notch cleavage. Nat.Cell.Biol. 3 507 PMID: 11331880

Petit et al (2003) JLK isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with Notch pathway in vitro or in vivo. J.Neurosci.Res. 74 370 PMID: 14598313

Hellstrom et al (2007) DII4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445 776 PMID: 17259973


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Keywords: inhibitors inhibits γ-secretase gamma-secretase mediated βAPP betaAPP processing Proteinases Proteases β-Amyloid beta-Amyloid b-amyloid Precursor Protein APP beta Peptides JLK6 amyloidbeta amyloidb amyloidβ Gamma-Secretase

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