Peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Binds to JNK with affinity in the micromolar range and minimally inhibits p38 and ERK.
(Modifications: Phe-11 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1341.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.75 mL||3.73 mL||7.45 mL|
|5 mM||0.15 mL||0.75 mL||1.49 mL|
|10 mM||0.07 mL||0.37 mL||0.75 mL|
|50 mM||0.01 mL||0.07 mL||0.15 mL|
References are publications that support the products' biological activity.
Barr et al (2002) Identification of the critical features of a small peptide inhibitor of JNK activity. J.Biol.Chem. 277 10987 PMID: 11790767
If you know of a relevant reference for JIP-1 (153-163), please let us know.
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Keywords: JIP-1 (153-163), supplier, JNK-selective, inhibitors, inhibits, peptide, c-Jun, N-Terminal, Kinase, SAPKs, Stress-Activated, Protein, MAPK, Mitogen-Activated, protein, TIJIP, TI-JIP, JNK/c-jun, JNK/c-jun, Tocris Bioscience
1 Citation for JIP-1 (153-163)
Citations are publications that use Tocris products. Selected citations for JIP-1 (153-163) include:
Kumar et al (2015) The Ser/Thr kinase MAP4K4 drives c-Met-induced motility and invasiveness in a cell-based model of SHH medulloblastoma. Springerplus 4 19 PMID: 25625039
Do you know of a great paper that uses JIP-1 (153-163) from Tocris? If so please let us know.
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Literature in this Area
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.