JIP-1 (153-163)

Pricing Availability Delivery Time Qty
Cat.No. 1565 - JIP-1 (153-163) | Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH2 | CAS No. 438567-88-5
Description: JNK-selective inhibitor peptide
Alternative Names: TI-JIP
Datasheet
Citations (1)
Reviews
Literature
Pathways

Biological Activity

Peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Binds to JNK with affinity in the micromolar range and minimally inhibits p38 and ERK.

Technical Data

M. Wt 1341.6
Formula C61H104N20O14
Sequence RPKRPTTLNLF

(Modifications: Phe-11 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 438567-88-5
PubChem ID 90479803
InChI Key BWQKOFMNXWAKES-QHYOMBHZSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1341.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.75 mL 3.73 mL 7.45 mL
5 mM 0.15 mL 0.75 mL 1.49 mL
10 mM 0.07 mL 0.37 mL 0.75 mL
50 mM 0.01 mL 0.07 mL 0.15 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Barr et al (2002) Identification of the critical features of a small peptide inhibitor of JNK activity. J.Biol.Chem. 277 10987 PMID: 11790767


If you know of a relevant reference for JIP-1 (153-163), please let us know.

View Related Products by Product Action

View all JNK/c-Jun Inhibitors

Keywords: JIP-1 (153-163), supplier, JNK-selective, inhibitors, inhibits, peptide, c-Jun, N-Terminal, Kinase, SAPKs, Stress-Activated, Protein, MAPK, Mitogen-Activated, protein, TIJIP, TI-JIP, JNK/c-jun, JNK/c-jun, Tocris Bioscience

1 Citation for JIP-1 (153-163)

Citations are publications that use Tocris products. Selected citations for JIP-1 (153-163) include:

Kumar et al (2015) The Ser/Thr kinase MAP4K4 drives c-Met-induced motility and invasiveness in a cell-based model of SHH medulloblastoma. Springerplus 4 19 PMID: 25625039


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Pathways for JIP-1 (153-163)

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.