ITH 12575

Pricing Availability Delivery Time Qty
Cat.No. 5692 - ITH 12575 | C18H18ClNOS | CAS No. 1802013-08-6
Description: Mitochondrial Na+/Ca2+ exchange (mNCX) inhibitor
Chemical Name: 7-Chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-4,1-benzothiazepin-2(3H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Mitochondrial Na+/Ca2+ exchange (mNCX) inhibitor. Reduces Ca2+ efflux from the mitochondria to the cytosol in HeLa cells (EC50 = 0.69 μM). Protects against glutamate-induced excitotoxitiy in rat hippocampal slices and oligomycin A/rotenone induced oxidative stress in neuroblastoma cells in vitro.

Technical Data

M. Wt 331.86
Formula C18H18ClNOS
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1802013-08-6
PubChem ID 124201848
InChI Key RDMUJSJZBYAAEF-UHFFFAOYSA-N
Smiles O=C1NC2=CC=C(Cl)C=C2C(C3=C(C(C)C)C=CC=C3)SC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 6.64 20
DMSO 33.19 100

Preparing Stock Solutions

The following data is based on the product molecular weight 331.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.07 mL 30.13 mL
5 mM 0.6 mL 3.01 mL 6.03 mL
10 mM 0.3 mL 1.51 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Martínez-Sanz et al (2015) Benzothiazepine CGP37157 analogues exert cytoprotection in various in vitro models of neurodegeneration. ACS Chem.Neurosci. 6 1626 PMID: 26192029

Moreno-Ortega et al (2015) Benzothiazepine CGP37157 and its 2'-isopropyl analogue modulate Ca2+ entry through CALHM1. Neuropharmacology 95 503 PMID: 25908402


If you know of a relevant reference for ITH 12575, please let us know.

View Related Products by Product Action

View all Na+/Ca2+ Exchanger Inhibitors

Keywords: ITH 12575, ITH 12575 supplier, ITH12575, sodium, calcium, exchangers, inhibitors, inhibits, Na+, Ca2+, exchange, neuroprotectant, neuroprotection, mitochondrial, mNCX, Na+/Ca2+, Exchanger, 5692, Tocris Bioscience

Citations for ITH 12575

Citations are publications that use Tocris products.

Currently there are no citations for ITH 12575. Do you know of a great paper that uses ITH 12575 from Tocris? Please let us know.

Reviews for ITH 12575

There are currently no reviews for this product. Be the first to review ITH 12575 and earn rewards!

Have you used ITH 12575?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure