ITH 12575

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Description: Mitochondrial Na+/Ca2+ exchange (mNCX) inhibitor
Chemical Name: 7-Chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-4,1-benzothiazepin-2(3H)-one
Purity: ≥98% (HPLC)

Biological Activity for ITH 12575

ITH 12575 is a mitochondrial Na+/Ca2+ exchange (mNCX) inhibitor. Reduces Ca2+ efflux from the mitochondria to the cytosol in HeLa cells (EC50 = 0.69 μM). Protects against glutamate-induced excitotoxitiy in rat hippocampal slices and oligomycin A/rotenone induced oxidative stress in neuroblastoma cells in vitro.

Compound Libraries for ITH 12575

ITH 12575 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ITH 12575

M. Wt 331.86
Formula C18H18ClNOS
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1802013-08-6
PubChem ID 124201848
Smiles O=C1NC2=CC=C(Cl)C=C2C(C3=C(C(C)C)C=CC=C3)SC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ITH 12575

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.19 100
ethanol 6.64 20

Preparing Stock Solutions for ITH 12575

The following data is based on the product molecular weight 331.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.07 mL 30.13 mL
5 mM 0.6 mL 3.01 mL 6.03 mL
10 mM 0.3 mL 1.51 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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References for ITH 12575

References are publications that support the biological activity of the product.

Martínez-Sanz et al (2015) Benzothiazepine CGP37157 analogues exert cytoprotection in various in vitro models of neurodegeneration. ACS Chem.Neurosci. 6 1626 PMID: 26192029

Moreno-Ortega et al (2015) Benzothiazepine CGP37157 and its 2'-isopropyl analogue modulate Ca2+ entry through CALHM1. Neuropharmacology 95 503 PMID: 25908402

If you know of a relevant reference for ITH 12575, please let us know.

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Citations for ITH 12575

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