Oligomycin A

Pricing Availability   Qty
Description: Inhibitor of mitochondrial ATPase
Chemical Name: (1R,4E,5'S,6S,6'S,7R,8S,10R,11R, 12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,9,13-trione
Purity: ≥98% (HPLC)
Citations (10)
Reviews (1)

Biological Activity for Oligomycin A

Oligomycin A is an inhibitor of mitochondrial ATP synthase and uncoupler of oxidative phosphorylation. Antibiotic; exhibits anti-tumor activity.

Technical Data for Oligomycin A

M. Wt 791.06
Formula C45H74O11
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 579-13-5
PubChem ID 5281899
Smiles CC[C@](CC[C@@]([H])(O[C@@]2(CC[C@@H](C)[C@@]([H])(C[C@@H](O)C)O2)[C@@H]1C)[C@H](C)[C@]1([H])OC(/C=C/[C@H]([C@@H]([C@@H](C)C([C@@H](C)[C@H](O)[C@H]3C)=O)O)C)=O)([H])/C=C/C=C/C[C@H](C)[C@@H](O)[C@](C)(O)C3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Oligomycin A

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 7.91 10

Preparing Stock Solutions for Oligomycin A

The following data is based on the product molecular weight 791.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 12.64 mL 63.21 mL 126.41 mL
0.5 mM 2.53 mL 12.64 mL 25.28 mL
1 mM 1.26 mL 6.32 mL 12.64 mL
5 mM 0.25 mL 1.26 mL 2.53 mL

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Product Datasheets for Oligomycin A

Certificate of Analysis / Product Datasheet
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References for Oligomycin A

References are publications that support the biological activity of the product.

Salomon et al (2001) Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. Chem.Biol. 8 71 PMID: 11182320

If you know of a relevant reference for Oligomycin A, please let us know.

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Keywords: Oligomycin A, Oligomycin A supplier, OligomycinA, inhibitors, mitochondrial, ATPase, inhibits, oxidative, phosphorylation, antibiotics, Other, ATPases, Antibiotics, 4110, Tocris Bioscience

10 Citations for Oligomycin A

Citations are publications that use Tocris products. Selected citations for Oligomycin A include:

Banh et al (2016) PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nat Cell Biol 18 803 PMID: 27323329

Depaoli et al (2018) Real-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of Single Cells. Cell Rep 25 501 PMID: 30304688

Roland C et al (2013) The ToxBank Data Warehouse: Supporting the Replacement of In Vivo Repeated Dose Systemic Toxicity Testing. Mol Inform 32 47-63 PMID: 27481023

Roland et al (2020) Metabolic Profiling of Single Cancer Cells Using Mitochondrial ATP Probes. STAR Protoc 1 100048 PMID: 33111094

Do you know of a great paper that uses Oligomycin A from Tocris? Please let us know.

Reviews for Oligomycin A

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Oligomycin A was used in oxidative phosphorylation studies.
By Jade Smith on 02/05/2019
Assay Type: In Vivo
Species: Mouse

Oligomycin A was used in oxidative phosphorylation studies. Its action on protein channel blocking was being studied. Performed well and gives repeatable results.

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