Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewOligomycin A
Description: Inhibitor of mitochondrial ATPase
Chemical Name: (1R,4E,5'S,6S,6'S,7R,8S,10R,11R, 12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,9,13-trione
Purity: ≥98% (HPLC)
Biological Activity for Oligomycin A
Oligomycin A is an inhibitor of mitochondrial ATP synthase and uncoupler of oxidative phosphorylation. Antibiotic; exhibits anti-tumor activity.
Technical Data for Oligomycin A
| M. Wt | 791.06 |
| Formula | C45H74O11 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 579-13-5 |
| PubChem ID | 5281899 |
| InChI Key | MNULEGDCPYONBU-WMBHJXFZSA-N |
| Smiles | CC[C@](CC[C@@]([H])(O[C@@]2(CC[C@@H](C)[C@@]([H])(C[C@@H](O)C)O2)[C@@H]1C)[C@H](C)[C@]1([H])OC(/C=C/[C@H]([C@@H]([C@@H](C)C([C@@H](C)[C@H](O)[C@H]3C)=O)O)C)=O)([H])/C=C/C=C/C[C@H](C)[C@@H](O)[C@](C)(O)C3=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Oligomycin A
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 7.91 | 10 |
Preparing Stock Solutions for Oligomycin A
The following data is based on the product molecular weight 791.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 12.64 mL | 63.21 mL | 126.41 mL |
| 0.5 mM | 2.53 mL | 12.64 mL | 25.28 mL |
| 1 mM | 1.26 mL | 6.32 mL | 12.64 mL |
| 5 mM | 0.25 mL | 1.26 mL | 2.53 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Oligomycin A
References for Oligomycin A
References are publications that support the biological activity of the product.
Salomon et al (2001) Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. Chem.Biol. 8 71 PMID: 11182320
If you know of a relevant reference for Oligomycin A, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Oligomycin A, Oligomycin A supplier, OligomycinA, inhibitors, mitochondrial, ATPase, inhibits, oxidative, phosphorylation, antibiotics, Other, ATPases, Antibiotics, 4110, Tocris Bioscience
3 Citations for Oligomycin A
Citations are publications that use Tocris products. Selected citations for Oligomycin A include:
Shin et al (2017) Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice. Cell Metab 26 764 PMID: 28988822
Depaoli et al (2018) Real-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of Single Cells. Cell Rep 25 501 PMID: 30304688
Banh et al (2016) PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nat Cell Biol 18 803 PMID: 27323329
Do you know of a great paper that uses Oligomycin A from Tocris? Please let us know.
Reviews for Oligomycin A
Average Rating: 4 (Based on 1 Review.)
Have you used Oligomycin A?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Oligomycin A was used in oxidative phosphorylation studies.
By
Jade Smith on 02/05/2019
Assay Type: In Vivo
Species: Mouse
Oligomycin A was used in oxidative phosphorylation studies. Its action on protein channel blocking was being studied. Performed well and gives repeatable results.
