Oligomycin A

Pricing Availability   Qty
Description: Inhibitor of mitochondrial ATPase
Chemical Name: (1R,4E,5'S,6S,6'S,7R,8S,10R,11R, 12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,9,13-trione
Purity: ≥98% (HPLC)
Datasheet
Citations (10)
Reviews (1)

Biological Activity for Oligomycin A

Oligomycin A is an inhibitor of mitochondrial ATP synthase and uncoupler of oxidative phosphorylation. Antibiotic; exhibits anti-tumor activity.

Technical Data for Oligomycin A

M. Wt 791.06
Formula C45H74O11
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 579-13-5
PubChem ID 5281899
InChI Key MNULEGDCPYONBU-WMBHJXFZSA-N
Smiles CC[C@](CC[C@@]([H])(O[C@@]2(CC[C@@H](C)[C@@]([H])(C[C@@H](O)C)O2)[C@@H]1C)[C@H](C)[C@]1([H])OC(/C=C/[C@H]([C@@H]([C@@H](C)C([C@@H](C)[C@H](O)[C@H]3C)=O)O)C)=O)([H])/C=C/C=C/C[C@H](C)[C@@H](O)[C@](C)(O)C3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Oligomycin A

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 7.91 10

Preparing Stock Solutions for Oligomycin A

The following data is based on the product molecular weight 791.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 12.64 mL 63.21 mL 126.41 mL
0.5 mM 2.53 mL 12.64 mL 25.28 mL
1 mM 1.26 mL 6.32 mL 12.64 mL
5 mM 0.25 mL 1.26 mL 2.53 mL

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Product Datasheets for Oligomycin A

Certificate of Analysis / Product Datasheet
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References for Oligomycin A

References are publications that support the biological activity of the product.

Salomon et al (2001) Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. Chem.Biol. 8 71 PMID: 11182320


If you know of a relevant reference for Oligomycin A, please let us know.

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Keywords: Oligomycin A, Oligomycin A supplier, OligomycinA, inhibitors, mitochondrial, ATPase, inhibits, oxidative, phosphorylation, antibiotics, Other, ATPases, Antibiotics, 4110, Tocris Bioscience

10 Citations for Oligomycin A

Citations are publications that use Tocris products. Selected citations for Oligomycin A include:

P Darrell et al (2021) Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia. Elife 10 PMID: 34132194

Kurt I et al (2021) Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms. Cell Rep 34 108750 PMID: 33596424

Hongbo et al (2021) Investigating the Dynamic Changes in iNKT Cell Metabolic Profiles During Development. Methods Mol Biol 2388 181-192 PMID: 34524673

Bernd et al (2021) The HSV-1 Transcription Factor ICP4 Confers Liquid-Like Properties to Viral Replication Compartments. Int J Mol Sci 22 PMID: 33923223


Do you know of a great paper that uses Oligomycin A from Tocris? Please let us know.

Reviews for Oligomycin A

Average Rating: 4 (Based on 1 Review.)

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Oligomycin A was used in oxidative phosphorylation studies.
By Jade Smith on 02/05/2019
Assay Type: In Vivo
Species: Mouse

Oligomycin A was used in oxidative phosphorylation studies. Its action on protein channel blocking was being studied. Performed well and gives repeatable results.

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