Oligomycin A

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Cat.No. 4110 - Oligomycin A | C45H74O11 | CAS No. 579-13-5
Description: Inhibitor of mitochondrial ATPase
Chemical Name: (1R,4E,5'S,6S,6'S,7R,8S,10R,11R, 12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,9,13-trione
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews (1)
Literature (1)

Biological Activity

Inhibitor of mitochondrial ATP synthase and uncoupler of oxidative phosphorylation. Antibiotic; exhibits anti-tumor activity.

Technical Data

M. Wt 791.06
Formula C45H74O11
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 579-13-5
PubChem ID 5281899
InChI Key MNULEGDCPYONBU-WMBHJXFZSA-N
Smiles CC[C@](CC[C@@]([H])(O[C@@]2(CC[C@@H](C)[C@@]([H])(C[C@@H](O)C)O2)[C@@H]1C)[C@H](C)[C@]1([H])OC(/C=C/[C@H]([C@@H]([C@@H](C)C([C@@H](C)[C@H](O)[C@H]3C)=O)O)C)=O)([H])/C=C/C=C/C[C@H](C)[C@@H](O)[C@](C)(O)C3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 7.91 10

Preparing Stock Solutions

The following data is based on the product molecular weight 791.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 12.64 mL 63.21 mL 126.41 mL
0.5 mM 2.53 mL 12.64 mL 25.28 mL
1 mM 1.26 mL 6.32 mL 12.64 mL
5 mM 0.25 mL 1.26 mL 2.53 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Salomon et al (2001) Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. Chem.Biol. 8 71 PMID: 11182320


If you know of a relevant reference for Oligomycin A, please let us know.

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Keywords: Oligomycin A, Oligomycin A supplier, OligomycinA, inhibitors, mitochondrial, ATPase, inhibits, oxidative, phosphorylation, antibiotics, Other, ATPases, Antibiotics, 4110, Tocris Bioscience

3 Citations for Oligomycin A

Citations are publications that use Tocris products. Selected citations for Oligomycin A include:

Depaoli et al (2018) Real-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of Single Cells. Cell Rep 25 501 PMID: 30304688

Banh et al (2016) PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nat Cell Biol 18 803 PMID: 27323329

Shin et al (2017) Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice. Cell Metab 26 764 PMID: 28988822


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Reviews for Oligomycin A

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Oligomycin A was used in oxidative phosphorylation studies.
By Jade Smith on 02/05/2019
Assay Type: In Vivo
Species: Mouse

Oligomycin A was used in oxidative phosphorylation studies. Its action on protein channel blocking was being studied. Performed well and gives repeatable results.

review image

Literature in this Area

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