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Biological Activity for IT 901
IT 901 is a c-Rel inhibitor (IC50 = 3 μM). Inhibits IL-2 expression in activated T-cells in vitro. Reduces severity of graft-versus-host disease following hematopoietic stem cell transplant (HSCT) and inhibits growth of human B-cell lymphoma xenografts in mice. Inhibits the oxidative stress response in lymphoma cells.
Technical Data for IT 901
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for IT 901
References are publications that support the biological activity of the product.
Shono et al (2016) Characterization of a c-Rel inhibitor that mediates anticancer properties in hematologic malignancies by blocking NF-κB-controlled oxidative stress responses. Cancer Res. 76 377 PMID: 26744524
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Keywords: IT 901, IT 901 supplier, IT901, NF-KB, NF-KappaB, NF-κB, c-Rel, subunit, inhibitors, inhibits, oxidative, stress, response, anticancer, NF-kB/IkB, 5846, Tocris Bioscience
Citations for IT 901
Citations are publications that use Tocris products.
Currently there are no citations for IT 901.
Reviews for IT 901
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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