IT 901

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Cat.No. 5846 - IT 901 | C17H14N2O4S | CAS No. 1584121-99-2
Description: NF-κB c-Rel subunit inhibitor
Chemical Name: 5-[(2,4-Dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
Purity: ≥98% (HPLC)
Literature (3)
Pathways (1)

Biological Activity for IT 901

IT 901 is a c-Rel inhibitor (IC50 = 3 μM). Inhibits IL-2 expression in activated T-cells in vitro. Reduces severity of graft-versus-host disease following hematopoietic stem cell transplant (HSCT) and inhibits growth of human B-cell lymphoma xenografts in mice. Inhibits the oxidative stress response in lymphoma cells.

Technical Data for IT 901

M. Wt 342.37
Formula C17H14N2O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1584121-99-2
PubChem ID 90082813
Smiles COC1=C(C=CC=C2)C2=C(/C=C3C(NC(NC/3=O)=S)=O)C(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for IT 901

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.24 100

Preparing Stock Solutions for IT 901

The following data is based on the product molecular weight 342.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.92 mL 14.6 mL 29.21 mL
5 mM 0.58 mL 2.92 mL 5.84 mL
10 mM 0.29 mL 1.46 mL 2.92 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets for IT 901

Certificate of Analysis / Product Datasheet
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References for IT 901

References are publications that support the biological activity of the product.

Shono et al (2016) Characterization of a c-Rel inhibitor that mediates anticancer properties in hematologic malignancies by blocking NF-κB-controlled oxidative stress responses. Cancer Res. 76 377 PMID: 26744524

If you know of a relevant reference for IT 901, please let us know.

View Related Products by Product Action

View all NF-κB and IκB Inhibitors

Keywords: IT 901, IT 901 supplier, IT901, NF-KB, NF-KappaB, NF-κB, c-Rel, subunit, inhibitors, inhibits, oxidative, stress, response, anticancer, NF-kB/IkB, 5846, Tocris Bioscience

Citations for IT 901

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Literature in this Area

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Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

Pathways for IT 901


NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.