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Biological Activity for Isoginkgetin
Isoginkgetin is a pre-mRNA splicing inhibitor (IC50 ~ 30 μM); inhibits major and minor spliceosomes. Suppresses transcriptional elongation. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage. Does not inhibit CDK9. Inhibits tumor cell invasion. Active in vivo. Cell permeable
Technical Data for Isoginkgetin
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Isoginkgetin
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Isoginkgetin
The following data is based on the product molecular weight 566.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.77 mL||8.83 mL||17.65 mL|
|5 mM||0.35 mL||1.77 mL||3.53 mL|
|10 mM||0.18 mL||0.88 mL||1.77 mL|
|50 mM||0.04 mL||0.18 mL||0.35 mL|
References for Isoginkgetin
References are publications that support the biological activity of the product.
O'Brien et al (2008) The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing. J.Biol.Chem. 283 33147 PMID: 18826947
Szewczak et al (2017) The right tool for the job. Cell 169 561 PMID: 28475886
Boswell et al (2017) Total RNA-seq to identify pharmacological effects on specific stages of mRNA synthesis. Nat.Chem.Biol. 13 501 PMID: 28263964
If you know of a relevant reference for Isoginkgetin, please let us know.
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Keywords: Isoginkgetin, Isoginkgetin supplier, mRNA, splicing, inhibitors, inhibits, cell-permeable, spliceosomes, transcriptional, elongation, DNA,, RNA, and, Protein, Synthesis, 6483, Tocris Bioscience
1 Citation for Isoginkgetin
Citations are publications that use Tocris products. Selected citations for Isoginkgetin include:
Sharon A et al (2021) Alternative splicing is a developmental switch for hTERT expression. Mol Cell 81 2349-2360.e6 PMID: 33852895
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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