Isoginkgetin

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Cat.No. 6483 - Isoginkgetin | C32H22O10 | CAS No. 548-19-6
Description: Pre-mRNA splicing inhibitor; cell permeable
Chemical Name: 8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Pre-mRNA splicing inhibitor (IC50 ~ 30 μM); inhibits major and minor spliceosomes. Suppresses transcriptional elongation. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage. Does not inhibit CDK9. Inhibits tumor cell invasion. Active in vivo. Cell permeable

Technical Data

M. Wt 566.51
Formula C32H22O10
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 548-19-6
PubChem ID 5318569
InChI Key HUOOMAOYXQFIDQ-UHFFFAOYSA-N
Smiles COC1=CC=C(C2=CC(C3=C(C=C(C(C4=CC(C5=CC(C6=C(C=C(C=C6O5)O)O)=O)=CC=C4OC)=C3O2)O)O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 56.65 100

Preparing Stock Solutions

The following data is based on the product molecular weight 566.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.77 mL 8.83 mL 17.65 mL
5 mM 0.35 mL 1.77 mL 3.53 mL
10 mM 0.18 mL 0.88 mL 1.77 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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References

References are publications that support the biological activity of the product.

O'Brien et al (2008) The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing. J.Biol.Chem. 283 33147 PMID: 18826947

Szewczak et al (2017) The right tool for the job. Cell 169 561 PMID: 28475886

Boswell et al (2017) Total RNA-seq to identify pharmacological effects on specific stages of mRNA synthesis. Nat.Chem.Biol. 13 501 PMID: 28263964


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Keywords: Isoginkgetin, Isoginkgetin supplier, mRNA, splicing, inhibitors, inhibits, cell-permeable, spliceosomes, transcriptional, elongation, DNA,, RNA, and, Protein, Synthesis, 6483, Tocris Bioscience

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