ProINDY

Pricing Availability Delivery Time Qty
Cat.No. 4998 - ProINDY | C14H15NO3S | CAS No. 719277-30-2
Description: DYRK1A/B inhibitor; prodrug of INDY (Cat. No. 4997)
Chemical Name: (1Z)-1-(5-Acetyloxy3-ethyl-2(3H)-benzothiazolylidene)-2-propanone
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

DYRK1A/B inhibitor; prodrug form of INDY (Cat. No. 4997). Cell permeable. Inhibits phosphorylation of tau protein and rescues repressed calcineurin/NFAT signaling. Recovers Xenopus embryos from head malformation induced by DYRK1A overexpression in vivo.

Technical Data

M. Wt 277.34
Formula C14H15NO3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 719277-30-2
PubChem ID 68879595
InChI Key RLEOCVDWLAYGRX-UHFFFAOYSA-N
Smiles O=C(C)/C=C1SC2=CC=C(OC(C)=O)C=C2N\1CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 277.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.61 mL 18.03 mL 36.06 mL
5 mM 0.72 mL 3.61 mL 7.21 mL
10 mM 0.36 mL 1.8 mL 3.61 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Ogawa et al (2010) Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nat.Commun. 1 86 PMID: 20981014


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Keywords: ProINDY, ProINDY supplier, downs, syndrome-related, kinases, Dyrk1A/B, inhibitors, inhibits, tau, phosphorylation, hyperphosphorylation, calcineurin, NFAT, neural, stem, cells, DYRK, 4998, Tocris Bioscience

1 Citation for ProINDY

Citations are publications that use Tocris products. Selected citations for ProINDY include:

Seu et al (2015) Stable Phenotypic Changes of the Host T Cells Are Essential to the Long-Term Stability of Latent HIV-1 Infection. Sci Rep 89 6656 PMID: 25878110


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Literature in this Area

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