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Biological Activity for IDR 1002
IDR 1002 is an innate defence regulator peptide. It reduces bacterial burden and inflammatory responses in murine models of sinusitis infection and bacterial acute lung infection. It inhibits LPS-induced NF-κB and COX-2 and induces the phosphorylation/activation of p38, ERK1/2, MSK1, and CREB.
Technical Data for IDR 1002
Modifications: Lys-12; C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for IDR 1002
|Solubility||Soluble to 1 mg/ml in water|
References for IDR 1002
References are publications that support the biological activity of the product.
Alford et al (2021) Murine model of sinusitis infection for screening antimicrobial and immunomodulatory therapies. Front.Cell.Infect.Microbiol. 11 621081 PMID: 33777834
Wuerth et al (2018) Characterization of host responses during pseudomonas aeruginosa acute infection in the lungs and blood and after treatment with the synthetic immunomodulatory peptide IDR-1002. Infect.Immun. 87 e00661 PMID: 30323028
Huante-Mendoza et al (2016) Peptide IDR-1002 inhibits NF-κB nuclear translocation by inhibition of IκBα degradation and activates p38/ERK1/2-MSK1-dependent CREB phosphorylation in macrophages stimulated with lipopolysaccharide. Front.Immunol. 7 533 PMID: 27933067
If you know of a relevant reference for IDR 1002, please let us know.
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Keywords: IDR 1002, IDR 1002 supplier, IDR1002, antimicrobial, host-defense, peptides, inflammation, sinusitis, lung, infection, in, vivo, CREB, COX2, cytokines, IDR, innate, defence, response, peptide, p38, ERK, NF-kB/IkB, Cytokines, 7866, Tocris Bioscience
Citations for IDR 1002
Citations are publications that use Tocris products.
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Literature in this Area
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