IDR 1002

Name: IDR 1002
Brand: Tocris Bioscience
SKU: 7866

Cat. No. 7866 Submit a Review Datasheet / COA / SDS

Discontinued Product

7866 has been discontinued.

View all NF-κB and IκB products.

Description: Innate defence regulator peptide

Purity: ≥95% (HPLC)

Datasheet

Citations

Reviews

Pathways (1)

Biological Activity Technical Data Datasheets References

Biological Activity for IDR 1002

IDR 1002 is an innate defence regulator peptide. It reduces bacterial burden and inflammatory responses in murine models of sinusitis infection and bacterial acute lung infection. It inhibits LPS-induced NF-κB and COX-2 and induces the phosphorylation/activation of p38, ERK1/2, MSK1, and CREB.

Technical Data for IDR 1002

M. Wt	1652.06
Formula	C₇₉H₁₃₀N₂₆O₁₃
Sequence	VQRWLIVWRIRK Modifications: Lys-12; C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1224095-25-3
PubChem ID	166603919
InChI Key	SEBZWKNTKRJFDZ-BRVBZNILSA-N
Smiles	O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for IDR 1002

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for IDR 1002

References are publications that support the biological activity of the product.

Alford et al (2021) Murine model of sinusitis infection for screening antimicrobial and immunomodulatory therapies. Front.Cell.Infect.Microbiol. 11 621081 PMID: 33777834

Wuerth et al (2018) Characterization of host responses during pseudomonas aeruginosa acute infection in the lungs and blood and after treatment with the synthetic immunomodulatory peptide IDR-1002. Infect.Immun. 87 e00661 PMID: 30323028

Huante-Mendoza et al (2016) Peptide IDR-1002 inhibits NF-κB nuclear translocation by inhibition of IκBα degradation and activates p38/ERK1/2-MSK1-dependent CREB phosphorylation in macrophages stimulated with lipopolysaccharide. Front.Immunol. 7 533 PMID: 27933067

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Keywords: IDR 1002, IDR 1002 supplier, IDR1002, antimicrobial, host-defense, peptides, inflammation, sinusitis, lung, infection, in, vivo, CREB, COX2, cytokines, IDR, innate, defence, response, peptide, p38, ERK, NF-kB/IkB, Cytokines, 7866, Tocris Bioscience

Citations for IDR 1002

Citations are publications that use Tocris products.

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Pathways for IDR 1002

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.