ICI 204,448 hydrochloride

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Cat.No. 0822 - ICI 204,448 hydrochloride | C23H26Cl2N2O4.HCl | CAS No. 121264-04-8
Description: κ agonist, acts peripherally
Chemical Name: (RS)-[3-[1-[[(3,4-Dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]acetic acid hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Peripherally acting κ agonist.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 501.84
Formula C23H26Cl2N2O4.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 121264-04-8
PubChem ID 129407
InChI Key FNDGLVOYAQNQPE-UHFFFAOYSA-N
Smiles Cl.CN(C(CN1CCCC1)C1=CC(OCC(O)=O)=CC=C1)C(=O)CC1=CC(Cl)=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 501.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.99 mL 9.96 mL 19.93 mL
5 mM 0.4 mL 1.99 mL 3.99 mL
10 mM 0.2 mL 1 mL 1.99 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Keïta et al (1995) Antinociceptive effect of a κ-opioid receptor agonist that minimally crosses the blood-brain barrier (ICI 204448) in a rat model of mononeuropathy. Eur.J.Pharmacol. 277 275 PMID: 7493620

Shaw et al (1989) ICI-204,448: a κ-opioid agonist with limited access to the CNS. Br.J.Pharmacol. 96 986 PMID: 2568146


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