ICI 204,448 hydrochloride

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Cat.No. 0822 - ICI 204,448 hydrochloride | C23H26Cl2N2O4.HCl | CAS No. 121264-04-8
Description: κ agonist, acts peripherally
Chemical Name: (RS)-[3-[1-[[(3,4-Dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]acetic acid hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Literature (5)

Biological Activity

Peripherally acting κ agonist.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 501.84
Formula C23H26Cl2N2O4.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 121264-04-8
PubChem ID 129407
InChI Key FNDGLVOYAQNQPE-UHFFFAOYSA-N
Smiles Cl.CN(C(CN1CCCC1)C1=CC(OCC(O)=O)=CC=C1)C(=O)CC1=CC(Cl)=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in DMSO

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Keïta et al (1995) Antinociceptive effect of a κ-opioid receptor agonist that minimally crosses the blood-brain barrier (ICI 204448) in a rat model of mononeuropathy. Eur.J.Pharmacol. 277 275 PMID: 7493620

Shaw et al (1989) ICI-204,448: a κ-opioid agonist with limited access to the CNS. Br.J.Pharmacol. 96 986 PMID: 2568146


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Keywords: ICI 204,448 hydrochloride, ICI 204,448 hydrochloride supplier, κ-opioid, kappa-opioid, agonists, peripherally, KOP, Receptors, OP2, ICI204448, hydrochloride, AstraZeneca, Kappa, Opioid, 0822, Tocris Bioscience

1 Citation for ICI 204,448 hydrochloride

Citations are publications that use Tocris products. Selected citations for ICI 204,448 hydrochloride include:

Butelman et al (2010) The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects. Psychopharmacology (Berl) 210 253 PMID: 20084367


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Reviews for ICI 204,448 hydrochloride

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Mouse EFS model.
By John Broad on 01/05/2018
Assay Type: In Vitro
Species: Mouse

Inhibited mouse GI EFS smooth muscle contractions

review image

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