ICI 204,448 hydrochloride

Pricing Availability   Qty
Description: κ agonist, acts peripherally
Chemical Name: (RS)-[3-[1-[[(3,4-Dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]acetic acid hydrochloride
Purity: ≥98% (HPLC)
Citations (1)
Reviews (1)
Literature (2)

Biological Activity for ICI 204,448 hydrochloride

ICI 204,448 hydrochloride is a peripherally acting κ agonist.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data for ICI 204,448 hydrochloride

M. Wt 501.84
Formula C23H26Cl2N2O4.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 121264-04-8
PubChem ID 129407
Smiles Cl.CN(C(CN1CCCC1)C1=CC(OCC(O)=O)=CC=C1)C(=O)CC1=CC(Cl)=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ICI 204,448 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 100

Preparing Stock Solutions for ICI 204,448 hydrochloride

The following data is based on the product molecular weight 501.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.99 mL 9.96 mL 19.93 mL
5 mM 0.4 mL 1.99 mL 3.99 mL
10 mM 0.2 mL 1 mL 1.99 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets for ICI 204,448 hydrochloride

Certificate of Analysis / Product Datasheet
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References for ICI 204,448 hydrochloride

References are publications that support the biological activity of the product.

Keïta et al (1995) Antinociceptive effect of a κ-opioid receptor agonist that minimally crosses the blood-brain barrier (ICI 204448) in a rat model of mononeuropathy. Eur.J.Pharmacol. 277 275 PMID: 7493620

Shaw et al (1989) ICI-204,448: a κ-opioid agonist with limited access to the CNS. Br.J.Pharmacol. 96 986 PMID: 2568146

If you know of a relevant reference for ICI 204,448 hydrochloride, please let us know.

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Keywords: ICI 204,448 hydrochloride, ICI 204,448 hydrochloride supplier, κ-opioid, kappa-opioid, agonists, peripherally, KOP, Receptors, OP2, ICI204448, hydrochloride, AstraZeneca, Kappa, Opioid, 0822, Tocris Bioscience

1 Citation for ICI 204,448 hydrochloride

Citations are publications that use Tocris products. Selected citations for ICI 204,448 hydrochloride include:

Butelman et al (2010) The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects. Psychopharmacology (Berl) 210 253 PMID: 20084367

Do you know of a great paper that uses ICI 204,448 hydrochloride from Tocris? Please let us know.

Reviews for ICI 204,448 hydrochloride

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Mouse EFS model.
By John Broad on 01/05/2018
Assay Type: In Vitro
Species: Mouse

Inhibited mouse GI EFS smooth muscle contractions

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Peptides Involved in Appetite Modulation Scientific Review

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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

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