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Description: Solubilization agent
Alternative Names: HBC,Hydroxypropyl-β-cyclodextrin
Citations (2)

Biological Activity for 2-Hydroxypropyl-β-cyclodextrin

The most widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with HBC.

Technical Data for 2-Hydroxypropyl-β-cyclodextrin

M. Wt 1400
Formula (C6H9O5)7(C3H7O)n
Storage Store at RT
CAS Number 128446-35-5
PubChem ID 44134771
Smiles O[C@@H]1[C@H]8C(COCC(C)O)O[C@H](O[C@H](C(COCC(C)O)O[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O[C@H](C(COCC(C)O)O[C@H](O[C@@H]5C(O)C(O)[C@H](O[C@@H]6C(O)C(O)[C@H](O[C@H](C(COCC(C)O)O[C@H](O8)[C@H]7O)[C@H]7O)O[C@@H]6COCC(C)O)O[C@@H]5COCC(C)O)[C@H]4O)[C@@H]4O)OC3COCC(C)O)[C@H]2O)[C@H]2O)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 2-Hydroxypropyl-β-cyclodextrin

Solvent Max Conc. mg/mL Max Conc. mM
water 140 100

Preparing Stock Solutions for 2-Hydroxypropyl-β-cyclodextrin

The following data is based on the product molecular weight 1400. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.71 mL 3.57 mL 7.14 mL
5 mM 0.14 mL 0.71 mL 1.43 mL
10 mM 0.07 mL 0.36 mL 0.71 mL
50 mM 0.01 mL 0.07 mL 0.14 mL

Molarity Calculator

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Product Datasheets for 2-Hydroxypropyl-β-cyclodextrin

Certificate of Analysis / Product Datasheet
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References for 2-Hydroxypropyl-β-cyclodextrin

References are publications that support the biological activity of the product.

Frijlink (1991) The effects of cyclodextrins on the disposition of intravenously injected drugs in the rat. Pharm.Res. 8 380 PMID: 2052529

Pitha et al (1986) Hydroxypropyl-β-cyclodextrin: preparation and characterisation; effects on solubility of drugs. Int.J.Pharmacol. 29 73

If you know of a relevant reference for 2-Hydroxypropyl-β-cyclodextrin, please let us know.

View Related Products by Target

Keywords: Hydroxypropyl-b-cyclodextrin, Hydroxypropyl-b-cyclodextrin supplier, Solubilization, agent, Reagents, cyclodextrin, Hydroxypropyl-beta-cyclodextrin, Hydroxypropyl-β-cyclodextrin, HBC, Hydroxypropyl-b-cyclodextrin, Biochemicals, and, Molecular, Biology, 0708, Tocris Bioscience

2 Citations for 2-Hydroxypropyl-β-cyclodextrin

Citations are publications that use Tocris products. Selected citations for 2-Hydroxypropyl-β-cyclodextrin include:

Marco et al (2016) Optogenetically enhanced pituitary corticotroph cell activity post-stress onset causes rapid organizing effects on behaviour. Nat Commun 7 12620 PMID: 27646867

Johnson et al (2012) Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network. Proc Natl Acad Sci U S A 107 733 PMID: 22554617

Do you know of a great paper that uses 2-Hydroxypropyl-β-cyclodextrin from Tocris? Please let us know.

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