2-Hydroxypropyl-β-cyclodextrin

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Cat.No. 0708 - Hydroxypropyl-b-cyclodextrin | (C6H9O5)7(C3H7O)n | CAS No. 128446-35-5
Description: Solubilization agent
Alternative Names: HBC, Hydroxypropyl-β-cyclodextrin
Datasheet
Citations (2)
Reviews
Literature (1)

Biological Activity

The most widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with HBC.

Technical Data

M. Wt 1400
Formula (C6H9O5)7(C3H7O)n
Storage Store at RT
CAS Number 128446-35-5
PubChem ID 44134771
InChI Key BZRWCHBEBFPRGF-UHFFFAOYSA-N
Smiles O[C@@H]1[C@H]8C(COCC(C)O)O[C@H](O[C@H](C(COCC(C)O)O[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O[C@H](C(COCC(C)O)O[C@H](O[C@@H]5C(O)C(O)[C@H](O[C@@H]6C(O)C(O)[C@H](O[C@H](C(COCC(C)O)O[C@H](O8)[C@H]7O)[C@H]7O)O[C@@H]6COCC(C)O)O[C@@H]5COCC(C)O)[C@H]4O)[C@@H]4O)OC3COCC(C)O)[C@H]2O)[C@H]2O)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 140 100

Preparing Stock Solutions

The following data is based on the product molecular weight 1400. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.71 mL 3.57 mL 7.14 mL
5 mM 0.14 mL 0.71 mL 1.43 mL
10 mM 0.07 mL 0.36 mL 0.71 mL
50 mM 0.01 mL 0.07 mL 0.14 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Frijlink (1991) The effects of cyclodextrins on the disposition of intravenously injected drugs in the rat. Pharm.Res. 8 380 PMID: 2052529

Pitha et al (1986) Hydroxypropyl-β-cyclodextrin: preparation and characterisation; effects on solubility of drugs. Int.J.Pharmacol. 29 73


If you know of a relevant reference for 2-Hydroxypropyl-β-cyclodextrin, please let us know.

View Related Products by Target

Keywords: Hydroxypropyl-b-cyclodextrin, Hydroxypropyl-b-cyclodextrin supplier, Solubilization, agent, Reagents, cyclodextrin, Hydroxypropyl-beta-cyclodextrin, Hydroxypropyl-β-cyclodextrin, HBC, Hydroxypropyl-b-cyclodextrin, Biochemicals, and, Molecular, Biology, 0708, Tocris Bioscience

2 Citations for 2-Hydroxypropyl-β-cyclodextrin

Citations are publications that use Tocris products. Selected citations for 2-Hydroxypropyl-β-cyclodextrin include:

Marco et al (2016) Optogenetically enhanced pituitary corticotroph cell activity post-stress onset causes rapid organizing effects on behaviour. Nat Commun 7 12620 PMID: 27646867

Johnson et al (2012) Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network. Proc Natl Acad Sci U S A 107 733 PMID: 22554617


Do you know of a great paper that uses 2-Hydroxypropyl-β-cyclodextrin from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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