Pricing Availability   Qty
Description: STAT5-SUMO protein-protein interaction inhibitor
Chemical Name: 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one
Purity: ≥98% (HPLC)
Pathways (1)

Biological Activity for HODHBt

HODHBt is a STAT5-SUMO protein-protein interaction inhibitor. Blocks SUMOylation of phosphorylated STAT5. Reactivates latent HIV-1 reservoir in central memory T cells (TCM). Increases viral release by ~2.7-fold at a concentration of 100 μM in combination with IL-2 compared to unstimulated cells; reduces size of latent HIV-1 reservoir in vitro.

Technical Data for HODHBt

M. Wt 163.14
Formula C7H5N3O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 28230-32-2
PubChem ID 73026
Smiles ON1N=NC2=CC=CC=C2C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for HODHBt

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 16.31 100
ethanol 8.16 50

Preparing Stock Solutions for HODHBt

The following data is based on the product molecular weight 163.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.13 mL 30.65 mL 61.3 mL
5 mM 1.23 mL 6.13 mL 12.26 mL
10 mM 0.61 mL 3.06 mL 6.13 mL
50 mM 0.12 mL 0.61 mL 1.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for HODHBt

References are publications that support the biological activity of the product.

Bosque et al (2017) Benzotriazoles reactivate latent HIV-1 through inactivation of STAT5 SUMOylation. Cell Rep. 18 1324 PMID: 28147284

If you know of a relevant reference for HODHBt, please let us know.

Keywords: HODHBt, HODHBt supplier, STAT5, SUMO, SUMOylation, protein-protein, interactions, inhibitors, inhibits, HIV-1, reservoir, STAT, HIV, 6994, Tocris Bioscience

Citations for HODHBt

Citations are publications that use Tocris products.

Currently there are no citations for HODHBt. Do you know of a great paper that uses HODHBt from Tocris? Please let us know.

Reviews for HODHBt

There are currently no reviews for this product. Be the first to review HODHBt and earn rewards!

Have you used HODHBt?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Pathways for HODHBt

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.