HODHBt

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Cat.No. 6994 - HODHBt | C7H5N3O2 | CAS No. 28230-32-2
Description: STAT5-SUMO protein-protein interaction inhibitor
Chemical Name: 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one
Purity: ≥98% (HPLC)
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Literature

Biological Activity

STAT5-SUMO protein-protein interaction inhibitor. Blocks SUMOylation of phosphorylated STAT5. Reactivates latent HIV-1 reservoir in central memory T cells (TCM). Increases viral release by ~2.7-fold at a concentration of 100 μM in combination with IL-2 compared to unstimulated cells; reduces size of latent HIV-1 reservoir in vitro.

Technical Data

M. Wt 163.14
Formula C7H5N3O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 28230-32-2
PubChem ID 73026
InChI Key HJBLUNHMOKFZQX-UHFFFAOYSA-N
Smiles ON1N=NC2=CC=CC=C2C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.31 100
ethanol 8.16 50

Preparing Stock Solutions

The following data is based on the product molecular weight 163.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.13 mL 30.65 mL 61.3 mL
5 mM 1.23 mL 6.13 mL 12.26 mL
10 mM 0.61 mL 3.06 mL 6.13 mL
50 mM 0.12 mL 0.61 mL 1.23 mL

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References

References are publications that support the biological activity of the product.

Bosque et al (2017) Benzotriazoles reactivate latent HIV-1 through inactivation of STAT5 SUMOylation. Cell Rep. 18 1324 PMID: 28147284


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Keywords: HODHBt, HODHBt supplier, STAT5, SUMO, SUMOylation, protein-protein, interactions, inhibitors, inhibits, HIV-1, reservoir, Antivirals, STAT, 6994, Tocris Bioscience

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