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Biological Activity for HODHBt
HODHBt is a STAT5-SUMO protein-protein interaction inhibitor. Blocks SUMOylation of phosphorylated STAT5. Reactivates latent HIV-1 reservoir in central memory T cells (TCM). Increases viral release by ~2.7-fold at a concentration of 100 μM in combination with IL-2 compared to unstimulated cells; reduces size of latent HIV-1 reservoir in vitro.
Technical Data for HODHBt
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for HODHBt
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for HODHBt
The following data is based on the product molecular weight 163.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.13 mL||30.65 mL||61.3 mL|
|5 mM||1.23 mL||6.13 mL||12.26 mL|
|10 mM||0.61 mL||3.06 mL||6.13 mL|
|50 mM||0.12 mL||0.61 mL||1.23 mL|
References for HODHBt
References are publications that support the biological activity of the product.
Bosque et al (2017) Benzotriazoles reactivate latent HIV-1 through inactivation of STAT5 SUMOylation. Cell Rep. 18 1324 PMID: 28147284
If you know of a relevant reference for HODHBt, please let us know.
Keywords: HODHBt, HODHBt supplier, STAT5, SUMO, SUMOylation, protein-protein, interactions, inhibitors, inhibits, HIV-1, reservoir, STAT, HIV, 6994, Tocris Bioscience
Citations for HODHBt
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Literature in this Area
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