HJC 0350

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Cat.No. 4844 - HJC 0350 | C15H19NO2S | CAS No. 885434-70-8
Description: Selective Epac2 inhibitor
Chemical Name: 2,4-Dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective Epac2 inhibitor (IC50 = 0.3 μM). Displays no effect on Epac1. Blocks stimulation of the Epac2-FL FRET sensor in HEK293 cells.

Compound Libraries

HJC 0350 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 277.38
Formula C15H19NO2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 885434-70-8
PubChem ID 22200891
InChI Key AFZWZVLPIMHLSE-UHFFFAOYSA-N
Smiles CC1=CC(C)=C(S(N2C(C)=CC(C)=C2)(=O)=O)C(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 13.87 50
ethanol 5.55 20

Preparing Stock Solutions

The following data is based on the product molecular weight 277.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.61 mL 18.03 mL 36.05 mL
5 mM 0.72 mL 3.61 mL 7.21 mL
10 mM 0.36 mL 1.8 mL 3.61 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Chen et al (2013) Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J.Med.Chem. 56 952 PMID: 23286832


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Keywords: HJC0350 EPAC EPAC2 epacs antagonists inhibitors inhibits exchange proteins directly activated by cAMP cyclic adenosine monophosphate GTPase

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Pathways for HJC 0350

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