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Submit ReviewHJC 0350
Description: Selective Epac2 inhibitor
Chemical Name: 2,4-Dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole
Purity: ≥98% (HPLC)
Biological Activity
Selective Epac2 inhibitor (IC50 = 0.3 μM). Displays no effect on Epac1. Blocks stimulation of the Epac2-FL FRET sensor in HEK293 cells.
Compound Libraries
HJC 0350 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 277.38 |
| Formula | C15H19NO2S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 885434-70-8 |
| PubChem ID | 22200891 |
| InChI Key | AFZWZVLPIMHLSE-UHFFFAOYSA-N |
| Smiles | CC1=CC(C)=C(S(N2C(C)=CC(C)=C2)(=O)=O)C(C)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 13.87 | 50 | |
| ethanol | 5.55 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 277.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 7.21 mL | 36.05 mL | 72.1 mL |
| 2.5 mM | 1.44 mL | 7.21 mL | 14.42 mL |
| 5 mM | 0.72 mL | 3.61 mL | 7.21 mL |
| 25 mM | 0.14 mL | 0.72 mL | 1.44 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Chen et al (2013) Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J.Med.Chem. 56 952 PMID: 23286832
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Keywords: HJC 0350, HJC 0350 supplier, HJC0350, EPAC, EPAC2, epacs, antagonists, inhibitors, inhibits, exchange, proteins, directly, activated, by, cAMP, Rap, guanine, nucleotide, factor, 4, RAPGEF4, GEFI, 4844, Tocris Bioscience
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