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HJC 0350

Cat. No. 4844 Submit a Review Datasheet / COA / SDS
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Cat.No. 4844 - HJC 0350 | C15H19NO2S | CAS No. 885434-70-8
Description: Selective Epac2 inhibitor
Chemical Name: 2,4-Dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for HJC 0350

HJC 0350 is a selective Epac2 inhibitor (IC50 = 0.3 μM). Displays no effect on Epac1. Blocks stimulation of the Epac2-FL FRET sensor in HEK293 cells.

Compound Libraries for HJC 0350

HJC 0350 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for HJC 0350

M. Wt 277.38
Formula C15H19NO2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 885434-70-8
PubChem ID 22200891
InChI Key AFZWZVLPIMHLSE-UHFFFAOYSA-N
Smiles CC1=CC(C)=C(S(N2C(C)=CC(C)=C2)(=O)=O)C(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for HJC 0350

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 13.87 50
ethanol 5.55 20

Preparing Stock Solutions for HJC 0350

The following data is based on the product molecular weight 277.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.21 mL 36.05 mL 72.1 mL
2.5 mM 1.44 mL 7.21 mL 14.42 mL
5 mM 0.72 mL 3.61 mL 7.21 mL
25 mM 0.14 mL 0.72 mL 1.44 mL

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Product Datasheets for HJC 0350

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for HJC 0350

References are publications that support the biological activity of the product.

Chen et al (2013) Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J.Med.Chem. 56 952 PMID: 23286832

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Citations for HJC 0350

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