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Biological Activity for HJC 0350
HJC 0350 is a selective Epac2 inhibitor (IC50 = 0.3 μM). Displays no effect on Epac1. Blocks stimulation of the Epac2-FL FRET sensor in HEK293 cells.
Compound Libraries for HJC 0350
Technical Data for HJC 0350
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for HJC 0350
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for HJC 0350
The following data is based on the product molecular weight 277.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||7.21 mL||36.05 mL||72.1 mL|
|2.5 mM||1.44 mL||7.21 mL||14.42 mL|
|5 mM||0.72 mL||3.61 mL||7.21 mL|
|25 mM||0.14 mL||0.72 mL||1.44 mL|
References for HJC 0350
References are publications that support the biological activity of the product.
Chen et al (2013) Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J.Med.Chem. 56 952 PMID: 23286832
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Keywords: HJC 0350, HJC 0350 supplier, HJC0350, EPAC, EPAC2, epacs, antagonists, inhibitors, inhibits, exchange, proteins, directly, activated, by, cAMP, Rap, guanine, nucleotide, factor, 4, RAPGEF4, GEFI, 4844, Tocris Bioscience
2 Citations for HJC 0350
Citations are publications that use Tocris products. Selected citations for HJC 0350 include:
Derek C et al (2021) Regulation of Mitochondrial Function by Epac2 Contributes to Acute Inflammatory Hyperalgesia. J Neurosci 41 2883-2898 PMID: 33593853
Cheng-Mao et al (2018) The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability. J Biol Chem 293 717-730 PMID: 29158262
Do you know of a great paper that uses HJC 0350 from Tocris? Please let us know.
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