HJC 0350

Pricing Availability   Qty
Description: Selective Epac2 inhibitor
Chemical Name: 2,4-Dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for HJC 0350

HJC 0350 is a selective Epac2 inhibitor (IC50 = 0.3 μM). Displays no effect on Epac1. Blocks stimulation of the Epac2-FL FRET sensor in HEK293 cells.

Compound Libraries for HJC 0350

HJC 0350 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for HJC 0350

M. Wt 277.38
Formula C15H19NO2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 885434-70-8
PubChem ID 22200891
Smiles CC1=CC(C)=C(S(N2C(C)=CC(C)=C2)(=O)=O)C(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for HJC 0350

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 13.87 50
ethanol 5.55 20

Preparing Stock Solutions for HJC 0350

The following data is based on the product molecular weight 277.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.21 mL 36.05 mL 72.1 mL
2.5 mM 1.44 mL 7.21 mL 14.42 mL
5 mM 0.72 mL 3.61 mL 7.21 mL
25 mM 0.14 mL 0.72 mL 1.44 mL

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Product Datasheets for HJC 0350

Certificate of Analysis / Product Datasheet
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References for HJC 0350

References are publications that support the biological activity of the product.

Chen et al (2013) Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J.Med.Chem. 56 952 PMID: 23286832

If you know of a relevant reference for HJC 0350, please let us know.

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Keywords: HJC 0350, HJC 0350 supplier, HJC0350, EPAC, EPAC2, epacs, antagonists, inhibitors, inhibits, exchange, proteins, directly, activated, by, cAMP, Rap, guanine, nucleotide, factor, 4, RAPGEF4, GEFI, 4844, Tocris Bioscience

2 Citations for HJC 0350

Citations are publications that use Tocris products. Selected citations for HJC 0350 include:

Derek C et al (2021) Regulation of Mitochondrial Function by Epac2 Contributes to Acute Inflammatory Hyperalgesia. J Neurosci 41 2883-2898 PMID: 33593853

Cheng-Mao et al (2018) The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability. J Biol Chem 293 717-730 PMID: 29158262

Do you know of a great paper that uses HJC 0350 from Tocris? Please let us know.

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