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Ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. Exhibits antiangiogenic activity in endothelial cells in vitro. Also inhibits Hsp90 and impairs recovery from heat shock.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 574.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||17.4 mL||87.01 mL||174.01 mL|
|0.5 mM||3.48 mL||17.4 mL||34.8 mL|
|1 mM||1.74 mL||8.7 mL||17.4 mL|
|5 mM||0.35 mL||1.74 mL||3.48 mL|
References are publications that support the biological activity of the product.
Fukazawa et al (1994) Labeling of v-Src and BCR-ABL tyrosine kinases with [14C]herbimycin A and its use in the elucidation of the kinase inactivation mechanism. FEBS Lett. 340 155 PMID: 8131836
McCollum et al (2004) Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity. Exp.Eye Res. 78 987 PMID: 15051479
Duncan (2005) Inhibition of Hsp90 function delays and impairs recovery from heat shock. FEBS J. 272 5244 PMID: 16218955
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Keywords: Herbimycin A, Herbimycin A supplier, Hsp90, inhibitors, inhibits, Src, family, kinase, Heat, Shock, Protein, 90, p60v-src, p210BCR-ABL, Kinases, HerbimycinA, antibiotics, Antiangiogenics, Antibiotics, 1629, Tocris Bioscience
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