Herbimycin A

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Cat.No. 1629 - Herbimycin A | C30H42N2O9 | CAS No. 70563-58-5
Description: Src family kinase inhibitor. Also Hsp90 inhibitor
Chemical Name: (15R)-17-demethoxy-15-methoxy-11-O-methyl-geldanamycin
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. Exhibits antiangiogenic activity in endothelial cells in vitro. Also inhibits Hsp90 and impairs recovery from heat shock.

Technical Data

M. Wt 574.67
Formula C30H42N2O9
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 70563-58-5
PubChem ID 6436247
InChI Key MCAHMSDENAOJFZ-GDYSMBPZSA-N
Smiles O=C1C=C([C@H](OC)[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.75 10

Preparing Stock Solutions

The following data is based on the product molecular weight 574.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.4 mL 87.01 mL 174.01 mL
0.5 mM 3.48 mL 17.4 mL 34.8 mL
1 mM 1.74 mL 8.7 mL 17.4 mL
5 mM 0.35 mL 1.74 mL 3.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Fukazawa et al (1994) Labeling of v-Src and BCR-ABL tyrosine kinases with [14C]herbimycin A and its use in the elucidation of the kinase inactivation mechanism. FEBS Lett. 340 155 PMID: 8131836

McCollum et al (2004) Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity. Exp.Eye Res. 78 987 PMID: 15051479

Duncan (2005) Inhibition of Hsp90 function delays and impairs recovery from heat shock. FEBS J. 272 5244 PMID: 16218955


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Keywords: Herbimycin A, Herbimycin A supplier, Hsp90, inhibitors, inhibits, Src, family, kinase, Heat, Shock, Protein, 90, p60v-src, p210BCR-ABL, Kinases, HerbimycinA, antibiotics, Antiangiogenics, Antibiotics, 1629, Tocris Bioscience

Citations for Herbimycin A

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