Helianorphin-19

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Description: Opioid receptor (KOR) agonist
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (5)

Biological Activity for Helianorphin-19

Helianorphin-19 is a high affinity, potent and selective κ-opioid receptor (KOR) agonist (Ki = 25 nM; EC50 = 45 nM). Helianorphin-19 exhibits approximately 200-fold selectivity for KOR over μ and δ-opioid receptors. In vivo Helianorphin-19 shows potent peripheral analgesic efficacy in a mouse model of visceral pain without affecting motor coordination/sedation.

Technical Data for Helianorphin-19

M. Wt 1790.21
Formula C81H132N26O16S2
Sequence CYGGFLRRCIRPKLK

(Modifications: Cyclic peptide, Disulfide bridge: 1-9]

Storage Store at -20°C
Purity ≥95% (HPLC)
InChI Key WEJHFJXWIBZZTQ-AHUOXLFJSA-N
Smiles O=C(N[C@@H](CC1=CC=C(C=C1)O)C(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H]3CCCNC(N)=N)=O)=O)=O)=O)=O)=O)[C@H](CSSC[C@@H](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N4[C@@H](CCC4)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@H]5CCCCN)=O)=O)=O)=O)=O)=O)NC3=O)NC5=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Helianorphin-19

Solubility Soluble to 2 mg/ml in water

Product Datasheets for Helianorphin-19

References for Helianorphin-19

References are publications that support the biological activity of the product.

Muratspahić et al (2021) Design of a stable cyclic peptide analgesic derived from sunflower seeds that targets the κ-opioid receptor for the treatment of chronic abdominal pain. J.Med.Chem. 64 9042 PMID: 34162205


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Keywords: Helianorphin-19, Helianorphin-19 supplier, activates, opioid, kappa-opioid, agonists, agonism, KOP, Receptors, KOR, potent, selective, Kappa, Opioid, 7541, Tocris Bioscience

Citations for Helianorphin-19

Citations are publications that use Tocris products.

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Reviews for Helianorphin-19

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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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