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Cat.No. 4991 - HaXS8 | C35H43ClF4N6O8
Description: Chemical dimerizer
Chemical Name: N-[[4-[[(2-Amino-9-H-purin-6-yl)oxy]methyl]phenyl]methyl]-2-[4-[(18-chloro-3,6,9,12-tetraoxaoctadec-1yl)oxy]-2,3,5,6-tetrafluorophenoxy]acetamide

Biological Activity

Promotes covalent and irreversible HaloTag® and SNAP-tag® substrate dimerization. Cell permeable.

HaloTag is a trademark of Promega Corporation, and SNAP-tag is a trademark of New England BioLabs, Inc.

Technical Data

M. Wt 787.2
Formula C35H43ClF4N6O8
Storage Store at -20°C
PubChem ID 124201846

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 78.72 100

Preparing Stock Solutions

The following data is based on the product molecular weight 787.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.27 mL 6.35 mL 12.7 mL
5 mM 0.25 mL 1.27 mL 2.54 mL
10 mM 0.13 mL 0.64 mL 1.27 mL
50 mM 0.03 mL 0.13 mL 0.25 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Erhart et al (2013) Chemical development of intracellular protein heterodimerizers. Chem.Biol. 20 549 PMID: 3601644

If you know of a relevant reference for HaXS8, please let us know.

Keywords: HaXS8, supplier, promotes, covalent, irreversible, HaloTag, SNAP-tag, dimerization, dimerizer, cell, permeable, Biochemicals, and, Molecular, Biology, Tocris Bioscience

Citations for HaXS8

Citations are publications that use Tocris products.

Currently there are no citations for HaXS8. Do you know of a great paper that uses HaXS8 from Tocris? If so please let us know.

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Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for HaXS8


TODO: Add Protocols