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Description: Chemical dimerizer
Chemical Name: N-[[4-[[(2-Amino-9-H-purin-6-yl)oxy]methyl]phenyl]methyl]-2-[4-[(18-chloro-3,6,9,12-tetraoxaoctadec-1yl)oxy]-2,3,5,6-tetrafluorophenoxy]acetamide
Purity: ≥90% (HPLC)

Biological Activity for HaXS8

HaXS8 is a promotes covalent and irreversible HaloTag® and SNAP-tag® substrate dimerization. Cell permeable.

HaloTag is a trademark of Promega Corporation, and SNAP-tag is a trademark of New England BioLabs, Inc.

Technical Data for HaXS8

M. Wt 787.2
Formula C35H43ClF4N6O8
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 2080306-25-6
PubChem ID 124201846

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for HaXS8

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 78.72 100

Preparing Stock Solutions for HaXS8

The following data is based on the product molecular weight 787.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.27 mL 6.35 mL 12.7 mL
5 mM 0.25 mL 1.27 mL 2.54 mL
10 mM 0.13 mL 0.64 mL 1.27 mL
50 mM 0.03 mL 0.13 mL 0.25 mL

Molarity Calculator

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Product Datasheets for HaXS8

Certificate of Analysis / Product Datasheet
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References for HaXS8

References are publications that support the biological activity of the product.

Erhart et al (2013) Chemical development of intracellular protein heterodimerizers. Chem.Biol. 20 549 PMID: 23601644

Zimmermann et al (2014) Cell-permeant and photocleavable chemical inducer of dimerization. Angew Chem.Int.Ed.Engl. 53 4717 PMID: 24677313

If you know of a relevant reference for HaXS8, please let us know.

Keywords: HaXS8, HaXS8 supplier, promotes, covalent, irreversible, HaloTag, SNAP-tag, dimerization, dimerizer, cell, permeable, Biochemicals, and, Molecular, Biology, Protein, Dimerizers, 4991, Tocris Bioscience

Citations for HaXS8

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Currently there are no citations for HaXS8. Do you know of a great paper that uses HaXS8 from Tocris? Please let us know.

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