GSK 789472 hydrochloride

Discontinued Product

GSK 789472 hydrochloride (Cat. No. 3940) has been withdrawn from sale for commercial reasons.
Cat.No. 3940 - GSK 789472 hydrochloride | C15H21N3O.HCl | CAS No. 1257326-24-1
Description: D3 antagonist. Also D2 partial agonist
Chemical Name: 4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one
Purity: ≥99% (HPLC)
Literature (5)

Biological Activity

Selective dopamine D3 receptor antagonist and D2 partial agonist (pEC50 values are <5.5 and 8.3 respectively). Selective against the D4 receptor in both agonist and antagonist assays. Brain penetrant.

Technical Data

M. Wt 295.81
Formula C15H21N3O.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1257326-24-1
PubChem ID 57347570

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.


References are publications that support the biological activity of the product.

Holmes et al (2010) The identification of a selective DA D2 partial agonist, D3 antagonist displaying high levels of brain exposure. Bioorg.Med.Chem.Lett. 20 2013 PMID: 20153647

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Citations for GSK 789472 hydrochloride

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Currently there are no citations for GSK 789472 hydrochloride.

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