GSK 789472 hydrochloride

Discontinued Product

GSK 789472 hydrochloride (Cat. No. 3940) has been withdrawn from sale for commercial reasons.
Cat.No. 3940 - GSK 789472 hydrochloride | C15H21N3O.HCl | CAS No. 1257326-24-1
Description: D3 antagonist. Also D2 partial agonist
Chemical Name: 4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (5)

Biological Activity

Selective dopamine D3 receptor antagonist and D2 partial agonist (pEC50 values are <5.5 and 8.3 respectively). Selective against the D4 receptor in both agonist and antagonist assays. Brain penetrant.

Technical Data

M. Wt 295.81
Formula C15H21N3O.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1257326-24-1
PubChem ID 57347570
InChI Key BYJUVPWUMBVSTK-UHFFFAOYSA-N
Smiles O=C1N(CC3CCCCN3)CCN1C2=CC=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Holmes et al (2010) The identification of a selective DA D2 partial agonist, D3 antagonist displaying high levels of brain exposure. Bioorg.Med.Chem.Lett. 20 2013 PMID: 20153647

View Related Products by Target

View Related Products by Product Action

View all D3 Receptor Antagonists

Keywords: GSK 789472 hydrochloride, GSK 789472 hydrochloride supplier, GSK789472, hydrochloride, dopamine, receptors, dopaminergic, D2, partial, agonists, D3, antagonists, Receptors, 3940, Tocris Bioscience

Citations for GSK 789472 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for GSK 789472 hydrochloride.

Reviews for GSK 789472 hydrochloride

There are currently no reviews for this product. Be the first to review GSK 789472 hydrochloride and earn rewards!

Have you used GSK 789472 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Dopamine Receptors

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Addiction

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.