GSK 789472 hydrochloride

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Cat.No. 3940 - GSK 789472 hydrochloride | C15H21N3O.HCl | CAS No. 1257326-24-1
Description: D3 antagonist. Also D2 partial agonist
Chemical Name: 4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective dopamine D3 receptor antagonist and D2 partial agonist (pEC50 values are <5.5 and 8.3 respectively). Selective against the D4 receptor in both agonist and antagonist assays. Brain penetrant.

Technical Data

M. Wt 295.81
Formula C15H21N3O.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1257326-24-1
PubChem ID 57347570
InChI Key BYJUVPWUMBVSTK-UHFFFAOYSA-N
Smiles O=C1N(CC3CCCCN3)CCN1C2=CC=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.58 100
water 29.58 100

Preparing Stock Solutions

The following data is based on the product molecular weight 295.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.38 mL 16.9 mL 33.81 mL
5 mM 0.68 mL 3.38 mL 6.76 mL
10 mM 0.34 mL 1.69 mL 3.38 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Holmes et al (2010) The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure. Bioorg.Med.Chem.Lett. 20 2013 PMID: 20153647


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