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Cat.No. 6594 - GSHtracer | C21H21N3O3 | CAS No. 1479071-34-5
Description: Ratiometric glutathione (GSH) probe
Chemical Name: 2-Cyano-N,N-dimethyl-3-(2,3,6,7-tetrahydro-11-oxo-1H,5H,11H-[1]benzopyrano[6,7,8-ij]quinolizin-10-yl)-2-propenamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Ratiometric probe for measuring of glutathione (GSH) levels. Upon GSH binding, excitation/emission maximum λ shifts from 520/580 nm to 430/510 nm. F510/F580 ratio correlates with GSH concentration.

Technical Data

M. Wt 363.41
Formula C21H21N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1479071-34-5
PubChem ID 102344531
Smiles CN(C(/C(C#N)=C/C1=CC2=CC3=C4N(CCCC4=C2OC1=O)CCC3)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 7.27 20

Preparing Stock Solutions

The following data is based on the product molecular weight 363.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.76 mL 68.79 mL 137.59 mL
1 mM 2.75 mL 13.76 mL 27.52 mL
2 mM 1.38 mL 6.88 mL 13.76 mL
10 mM 0.28 mL 1.38 mL 2.75 mL

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References are publications that support the biological activity of the product.

Jeong et al (2018) Real-time monitoring of glutathione in living cells reveals that high glutathione levels are required to maintain stem cell function. Stem Cell Reports 10 600 PMID: 29307581

If you know of a relevant reference for GSHtracer, please let us know.

Keywords: GSHtracer, GSHtracer supplier, FreSH, tracer, glutathione, GSH, probe, fluorescent, ratiometric, measuring, measures, Fluorescent, Cell, Indicators, and, Sensors, 6594, Tocris Bioscience

Citations for GSHtracer

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Literature in this Area

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New Product Guide

New Product Guide [Spring/Summer 2019]

Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.

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