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Inhibitor of SUMOylation (IC50 = 3 μM). Directly binds E1 and inhibits formation of E1-SUMO intermediate. Protects against amyloid β-induced impairment of neurotransmission and synaptic plasticity. Also suppresses CD44 and MMP14 expression in breast cancer cells, eliminating cancer stem cells and inhibiting tumorigenesis.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 346.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.89 mL||14.43 mL||28.86 mL|
|5 mM||0.58 mL||2.89 mL||5.77 mL|
|10 mM||0.29 mL||1.44 mL||2.89 mL|
|50 mM||0.06 mL||0.29 mL||0.58 mL|
References are publications that support the biological activity of the product.
Fukuda et al (2009) Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. Chem.Biol. 16 133 PMID: 19246003
Mango et al (2016) Ginkgolic acid protects against Aβ-induced synaptic dysfunction in the hippocampus. Front.Pharmacol. 7 401 PMID: 27833555
Bogachek et al (2016) Inhibiting the SUMO pathway represses the cancer stem cell population in breast and colorectal carcinomas. Stem Cell Reports. 7 1140 PMID: 27916539
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Keywords: Ginkgolic Acid, Ginkgolic Acid supplier, inhibitors, inhibits, SUMOylation, ubiquitin, activating, enzyme, E1, neuroprotective, CD44, Other, Ligases, Post-translational, Modifications, Cancer, Stem, Cells, 6326, Tocris Bioscience
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