Ginkgolic Acid

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Description: Inhibits SUMOylation by binding E1
Chemical Name: 2-Hydroxy-6-(8Z)-8-pentadecenylbenzoic acid
Purity: ≥97% (HPLC)

Biological Activity for Ginkgolic Acid

Ginkgolic Acid is an inhibitor of SUMOylation (IC50 = 3 μM). Directly binds E1 and inhibits formation of E1-SUMO intermediate. Protects against amyloid β-induced impairment of neurotransmission and synaptic plasticity. Also suppresses CD44 and MMP14 expression in breast cancer cells, eliminating cancer stem cells and inhibiting tumorigenesis.

Technical Data for Ginkgolic Acid

M. Wt 346.5
Formula C22H34O3
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 22910-60-7
PubChem ID 5281858

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ginkgolic Acid

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.65 100
ethanol 34.65 100

Preparing Stock Solutions for Ginkgolic Acid

The following data is based on the product molecular weight 346.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.89 mL 14.43 mL 28.86 mL
5 mM 0.58 mL 2.89 mL 5.77 mL
10 mM 0.29 mL 1.44 mL 2.89 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets for Ginkgolic Acid

References for Ginkgolic Acid

References are publications that support the biological activity of the product.

Fukuda et al (2009) Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. Chem.Biol. 16 133 PMID: 19246003

Mango et al (2016) Ginkgolic acid protects against Aβ-induced synaptic dysfunction in the hippocampus. Front.Pharmacol. 7 401 PMID: 27833555

Bogachek et al (2016) Inhibiting the SUMO pathway represses the cancer stem cell population in breast and colorectal carcinomas. Stem Cell Reports. 7 1140 PMID: 27916539

If you know of a relevant reference for Ginkgolic Acid, please let us know.

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Keywords: Ginkgolic Acid, Ginkgolic Acid supplier, inhibitors, inhibits, SUMOylation, ubiquitin, activating, enzyme, E1, neuroprotective, CD44, SUMO, Other, Ligases, Post-translational, Modifications, Cancer, Stem, Cells, 6326, Tocris Bioscience

Citations for Ginkgolic Acid

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