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Submit ReviewGinkgolic Acid
Description: Inhibits SUMOylation by binding E1
Chemical Name: 2-Hydroxy-6-(8Z)-8-pentadecenylbenzoic acid
Purity: ≥97% (HPLC)
Biological Activity for Ginkgolic Acid
Ginkgolic Acid is an inhibitor of SUMOylation (IC50 = 3 μM). Directly binds E1 and inhibits formation of E1-SUMO intermediate. Protects against amyloid β-induced impairment of neurotransmission and synaptic plasticity. Also suppresses CD44 and MMP14 expression in breast cancer cells, eliminating cancer stem cells and inhibiting tumorigenesis.
Technical Data for Ginkgolic Acid
| M. Wt | 346.5 |
| Formula | C22H34O3 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 22910-60-7 |
| PubChem ID | 5281858 |
| InChI Key | YXHVCZZLWZYHSA-FPLPWBNLSA-N |
| Smiles | CCCCCC/C=C\CCCCCCCC1=C(C(O)=CC=C1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ginkgolic Acid
References for Ginkgolic Acid
References are publications that support the biological activity of the product.
Fukuda et al (2009) Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. Chem.Biol. 16 133 PMID: 19246003
Mango et al (2016) Ginkgolic acid protects against Aβ-induced synaptic dysfunction in the hippocampus. Front.Pharmacol. 7 401 PMID: 27833555
Bogachek et al (2016) Inhibiting the SUMO pathway represses the cancer stem cell population in breast and colorectal carcinomas. Stem Cell Reports. 7 1140 PMID: 27916539
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Keywords: Ginkgolic Acid, Ginkgolic Acid supplier, inhibitors, inhibits, SUMOylation, ubiquitin, activating, enzyme, E1, neuroprotective, CD44, SUMO, Other, Ligases, Post-translational, Modifications, Cancer, Stem, Cells, 6326, Tocris Bioscience
1 Citation for Ginkgolic Acid
Citations are publications that use Tocris products. Selected citations for Ginkgolic Acid include:
Yannick D et al (2021) Pharmacological targeting of Sam68 functions in colorectal cancer stem cells. iScience 24 103442 PMID: 34877499
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