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GLI antagonist that inhibits GLI1-induced transcription (IC50 = 5 μM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 392.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||10.19 mL||50.96 mL||101.92 mL|
|1.25 mM||2.04 mL||10.19 mL||20.38 mL|
|2.5 mM||1.02 mL||5.1 mL||10.19 mL|
|12.5 mM||0.2 mL||1.02 mL||2.04 mL|
References are publications that support the biological activity of the product.
Lauth et al (2007) Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc.Natl.Acad.Sci. 104 8455 PMID: 17494766
Beauchamp et al (2009) GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J.Biol.Chem. 284 9074 PMID: 19189974
Joo et al (2009) GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors. PLoS ONE 4 7608 PMID: 19859563
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Keywords: GANT 58, GANT 58 supplier, GANT58, GLI1, inhibits, inhibitors, downstream, Hedgehog, signalling, signaling, Gli, antagonists, Hh, Signaling, Stem, Cell, 3889, Tocris Bioscience
1 Citation for GANT 58
Citations are publications that use Tocris products. Selected citations for GANT 58 include:
Oladapo (2017) Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells. Cancer Lett 411 136 PMID: 28965853
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.