Ganaxolone

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Description: Potent positive allosteric modulator of GABAA receptors
Alternative Names: CCD 1042
Chemical Name: (3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity for Ganaxolone

Ganaxolone is a potent positive allosteric modulator of GABAA receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABAA receptors (EC50 values are 94, 122 and 213 nM for α2β1γ2L, α3β1γ2L and α1β1γ2L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.

Technical Data for Ganaxolone

M. Wt 332.53
Formula C22H36O2
Storage Store at +4°C
CAS Number 38398-32-2
PubChem ID 6918305
InChI Key PGTVWKLGGCQMBR-FLBATMFCSA-N
Smiles O[C@]1(C)CC[C@@]2(C)[C@](CC[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4[C@](C)=O)([H])C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ganaxolone

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.33 10 with gentle warming
ethanol 6.65 20

Preparing Stock Solutions for Ganaxolone

The following data is based on the product molecular weight 332.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 15.04 mL 75.18 mL 150.36 mL
1 mM 3.01 mL 15.04 mL 30.07 mL
2 mM 1.5 mL 7.52 mL 15.04 mL
10 mM 0.3 mL 1.5 mL 3.01 mL

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Product Datasheets for Ganaxolone

Certificate of Analysis / Product Datasheet
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References for Ganaxolone

References are publications that support the biological activity of the product.

Carter et al (1997) Characterization of the anticonvulsive properties of ganaxolone (CCD 1044; 3α-hydroxy-3β-methyl-5α-pregnan-20-one), a selective, high affinity, steroid modulator of the γ-aminobutyric acidA receptor. J.Pharmacol.Exp.Ther. 280 1284 PMID: 9067315

Lyden et al (2000) Effect of ganaxolone in a rodent model of cerebral hematoma. Stroke 31 169 PMID: 10625734

Ungard et al (2000) Modification of behavioral effects of drugs in mice by neuroactive steroids. Psychopharmacology 148 336 PMID: 10928304


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Keywords: Ganaxolone, Ganaxolone supplier, Potent, positive, allosteric, modulators, GABAA, receptors, Receptors, CCD1042, PAM, CCD, 1042, 2531, Tocris Bioscience

1 Citation for Ganaxolone

Citations are publications that use Tocris products. Selected citations for Ganaxolone include:

Asiedu et al (2012) Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice. J Pain 13 546 PMID: 22537560


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Reviews for Ganaxolone

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.