Gabapentin

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Cat.No. 0806 - Gabapentin | C9H17NO2 | CAS No. 60142-96-3
Description: Anticonvulsant. Increases brain GABA
Chemical Name: 1-(Aminomethyl)cyclohexaneacetic acid
Purity: ≥99%
Datasheet
Citations (1)
Literature

Biological Activity

Anticonvulsant with several possible mechanisms of action. Increases GABA in the brain and binds to a novel site associated with voltage-sensitive Ca2+ channels. Prevents neuronal death and is antinociceptive and anxiolytic.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 171.24
Formula C9H17NO2
Storage Desiccate at +4°C
Purity ≥99%
CAS Number 60142-96-3
PubChem ID 3446
InChI Key UGJMXCAKCUNAIE-UHFFFAOYSA-N
Smiles NCC1(CC(O)=O)CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
phosphate buffered saline 17.12 100
water 17.12 100mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 171.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.84 mL 29.2 mL 58.4 mL
5 mM 1.17 mL 5.84 mL 11.68 mL
10 mM 0.58 mL 2.92 mL 5.84 mL
50 mM 0.12 mL 0.58 mL 1.17 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Fink et al (2000) Inhibition of Ca2+ influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices. Br.J.Pharmacol. 130 900 PMID: 10864898

Taylor et al (1998) A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res. 29 233 PMID: 9551785

Timmerman et al (2000) A microdialysis study on the mechanism of action of gabapentin. Eur.J.Pharmacol. 398 53 PMID: 10856447

Upton (1994) Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings. TiPS 15 456 PMID: 7886818


If you know of a relevant reference for Gabapentin, please let us know.

Keywords: Gabapentin, supplier, Anticonvulsant, Increases, brain, GABA, Binds, voltage-sensitive, Ca2+, channels, GABAB, Receptors, GABAA, GABAC, Calcium, CaV, Channels, L-Type, P-Type, R-Type, Q-Type, T-Type, N-Type, voltage-gated, voltage-dependent, Pfizer, Miscellaneous, GABA, Tocris Bioscience

1 Citation for Gabapentin

Citations are publications that use Tocris products. Selected citations for Gabapentin include:

Sant'Anna et al (2016) Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization. J Neurosci 6 26955 PMID: 27230787


Do you know of a great paper that uses Gabapentin from Tocris? If so please let us know.

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Reviews

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Literature in this Area

GABA Receptors

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Pathways for Gabapentin

Protocols

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