Discontinued Product

Gabapentin (Cat. No. 0806) has been withdrawn from sale for commercial reasons.
Description: Increases brain GABA; anticonvulsant
Chemical Name: 1-(Aminomethyl)cyclohexaneacetic acid
Purity: ≥99%
Citations (1)
Literature (1)

Biological Activity for Gabapentin

Anticonvulsant with several possible mechanisms of action. Increases GABA in the brain and binds to a novel site associated with voltage-sensitive Ca2+ channels. Prevents neuronal death and is antinociceptive and anxiolytic.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for Gabapentin

M. Wt 171.24
Formula C9H17NO2
Storage Desiccate at +4°C
Purity ≥99%
CAS Number 60142-96-3
PubChem ID 3446
Smiles NCC1(CC(O)=O)CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Gabapentin

Certificate of Analysis / Product Datasheet
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References for Gabapentin

References are publications that support the biological activity of the product.

Fink et al (2000) Inhibition of Ca2+ influx by gabap. and subsequent reduction of neurotransmitter release from rat neocortical slices. Br.J.Pharmacol. 130 900 PMID: 10864898

Taylor et al (1998) A summary of mechanistic hypotheses of gabap. pharmacology. Epilepsy Res. 29 233 PMID: 9551785

Timmerman et al (2000) A microdialysis study on the mechanism of action of gabap. Eur.J.Pharmacol. 398 53 PMID: 10856447

Upton (1994) Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings. TiPS 15 456 PMID: 7886818

Keywords: Gabapentin, Gabapentin supplier, Anticonvulsant, Increases, brain, GABA, Binds, voltage-sensitive, Ca2+, channels, GABAB, Receptors, GABAA, GABAC, Calcium, CaV, Channels, L-Type, P-Type, R-Type, Q-Type, T-Type, N-Type, voltage-gated, voltage-dependent, Pfizer, Miscellaneous, Non-selective, Cav, 0806, Tocris Bioscience

1 Citation for Gabapentin

Citations are publications that use Tocris products. Selected citations for Gabapentin include:

Sant'Anna et al (2016) Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization. J Neurosci 6 26955 PMID: 27230787

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.