Anticonvulsant with several possible mechanisms of action. Increases GABA in the brain and binds to a novel site associated with voltage-sensitive Ca2+ channels. Prevents neuronal death and is antinociceptive and anxiolytic.
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||17.12||100mM with gentle warming|
|phosphate buffered saline||17.12||100|
Preparing Stock Solutions
The following data is based on the product molecular weight 171.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.84 mL||29.2 mL||58.4 mL|
|5 mM||1.17 mL||5.84 mL||11.68 mL|
|10 mM||0.58 mL||2.92 mL||5.84 mL|
|50 mM||0.12 mL||0.58 mL||1.17 mL|
References are publications that support the products' biological activity.
Fink et al (2000) Inhibition of Ca2+ influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices. Br.J.Pharmacol. 130 900 PMID: 10864898
Taylor et al (1998) A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res. 29 233 PMID: 9551785
Timmerman et al (2000) A microdialysis study on the mechanism of action of gabapentin. Eur.J.Pharmacol. 398 53 PMID: 10856447
Upton (1994) Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings. TiPS 15 456 PMID: 7886818
If you know of a relevant reference for Gabapentin, please let us know.
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Keywords: Gabapentin, supplier, Anticonvulsant, Increases, brain, GABA, Binds, voltage-sensitive, Ca2+, channels, GABAB, Receptors, GABAA, GABAC, Calcium, CaV, Channels, L-Type, P-Type, R-Type, Q-Type, T-Type, N-Type, voltage-gated, voltage-dependent, Pfizer, Miscellaneous, GABA, Voltage-gated, Calcium, Channels, GABAB, Receptors, Miscellaneous, GABA, Tocris Bioscience
1 Citation for Gabapentin
Citations are publications that use Tocris products. Selected citations for Gabapentin include:
Sant'Anna et al (2016) Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization. J Neurosci 6 26955 PMID: 27230787
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Literature in this Area
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.