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Discontinued ProductGabapentin (Cat. No. 0806) has been withdrawn from sale for commercial reasons.
Biological Activity for Gabapentin
Anticonvulsant with several possible mechanisms of action. Increases GABA in the brain and binds to a novel site associated with voltage-sensitive Ca2+ channels. Prevents neuronal death and is antinociceptive and anxiolytic.
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for Gabapentin
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for Gabapentin
References are publications that support the biological activity of the product.
Fink et al (2000) Inhibition of Ca2+ influx by gabap. and subsequent reduction of neurotransmitter release from rat neocortical slices. Br.J.Pharmacol. 130 900 PMID: 10864898
Taylor et al (1998) A summary of mechanistic hypotheses of gabap. pharmacology. Epilepsy Res. 29 233 PMID: 9551785
Timmerman et al (2000) A microdialysis study on the mechanism of action of gabap. Eur.J.Pharmacol. 398 53 PMID: 10856447
Upton (1994) Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings. TiPS 15 456 PMID: 7886818
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Keywords: Gabapentin, Gabapentin supplier, Anticonvulsant, Increases, brain, GABA, Binds, voltage-sensitive, Ca2+, channels, GABAB, Receptors, GABAA, GABAC, Calcium, CaV, Channels, L-Type, P-Type, R-Type, Q-Type, T-Type, N-Type, voltage-gated, voltage-dependent, Pfizer, Miscellaneous, Non-selective, Cav, 0806, Tocris Bioscience
1 Citation for Gabapentin
Citations are publications that use Tocris products. Selected citations for Gabapentin include:
Sant'Anna et al (2016) Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization. J Neurosci 6 26955 PMID: 27230787
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.