Chemosensitizing agent; selectively reverses BCRP-mediated multidrug resistance to mitoxantrone (Cat. No. 4250), doxorubicin (Cat. No. 2252) and topotecan (Cat. No. 4562) in transfected MCF-7 cells. Does not reverse resistance in P-gp- or MRP-positive cells. Analog (Ko 143, Cat. No. 3241) also available.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 379.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.64 mL||13.18 mL||26.35 mL|
|5 mM||0.53 mL||2.64 mL||5.27 mL|
|10 mM||0.26 mL||1.32 mL||2.64 mL|
|50 mM||0.05 mL||0.26 mL||0.53 mL|
References are publications that support the products' biological activity.
Rabindran et al (2000) Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Cancer Res. 60 PMID: 10646850
Rabindran et al (1998) Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C. Cancer Res. 58 5850 PMID: 9865745
If you know of a relevant reference for Fumitremorgin C, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Fumitremorgin C, supplier, mycotoxins, chemosensitisers, chemosensitizers, chemosensitizing, chemosensitising, BCRP, breast, cancer, resistance, proteins, reverses, multidrug, resistance, MDR, FumitremorginC, Multidrug, Transporters, Multidrug, Transporters, Tocris Bioscience
Citations for Fumitremorgin C
Citations are publications that use Tocris products.
Currently there are no citations for Fumitremorgin C. Do you know of a great paper that uses Fumitremorgin C from Tocris? If so please let us know.
Reviews for Fumitremorgin C
There are currently no reviews for this product. Be the first to review Fumitremorgin C and earn rewards!
Have you used Fumitremorgin C?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.