Fumitremorgin C

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Cat.No. 2876 - Fumitremorgin C | C22H25N3O3 | CAS No. 118974-02-0
Description: Inhibitor of BCRP-mediated multidrug resistance
Chemical Name: (5aS,12S,14aS)-1,2,3,5a,6,11,12,14a-Octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Chemosensitizing agent; selectively reverses BCRP-mediated multidrug resistance to mitoxantrone (Cat. No. 4250), doxorubicin (Cat. No. 2252) and topotecan (Cat. No. 4562) in transfected MCF-7 cells. Does not reverse resistance in P-gp- or MRP-positive cells. Analog (Ko 143, Cat. No. 3241) also available.

Technical Data

M. Wt 379.45
Formula C22H25N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 118974-02-0
PubChem ID 403923
InChI Key DBEYVIGIPJSTOR-FHWLQOOXSA-N
Smiles O=[C@@]3N5[C@@H](CCC5)C(N([C@H]3C4)[C@@H](/C=C(C)/C)C2=C4C1=CC=C(OC)C=C1N2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.79 10

Preparing Stock Solutions

The following data is based on the product molecular weight 379.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.35 mL 131.77 mL 263.54 mL
0.5 mM 5.27 mL 26.35 mL 52.71 mL
1 mM 2.64 mL 13.18 mL 26.35 mL
5 mM 0.53 mL 2.64 mL 5.27 mL

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References

References are publications that support the biological activity of the product.

Rabindran et al (2000) Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Cancer Res. 60 PMID: 10646850

Rabindran et al (1998) Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C. Cancer Res. 58 5850 PMID: 9865745


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