Type II DNA topoisomerase inhibitor. Disrupts DNA synthesis and repair and induces damage by DNA cross-linking. Also inhibits PIM1 kinase (IC50 = 51 nM). Immunomodulatory, antineoplastic and chemotherapeutic agent. Also USP11 inhibitor (IC50= 3.15 μM). Induces cell death of pancreatic cancer cell lines expressing wild-type BRCA2.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 517.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.75 mM||2.58 mL||12.88 mL||25.77 mL|
|3.75 mM||0.52 mL||2.58 mL||5.15 mL|
|7.5 mM||0.26 mL||1.29 mL||2.58 mL|
|37.5 mM||0.05 mL||0.26 mL||0.52 mL|
References are publications that support the biological activity of the product.
Scott and Figgit (2004) Mitoxantrone: a review of its uses in multiple sclerosis. CNS Drugs. 18 379 PMID: 15089110
Crespi et al (1986) Mitoxantrone affects topoisomerase activities in human breast cancer cells. Biochem.Biophys.Res.Comm. 136 521 PMID: 3010982
Wan et al (2013) A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling. J.Med.Chem. 56 2619 PMID: 23442188
Burkhart et al (2013) Mitoxantrone targets human ubiquitin-specific peptidase 11 (USP11) and is a potent inhibitor of pancreatic cancer cell survival. Mol.Cancer Res. 11 901 PMID: 23696131
If you know of a relevant reference for Mitoxantrone dihydrochloride, please let us know.
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Keywords: Mitoxantrone dihydrochloride, Mitoxantrone dihydrochloride supplier, topoisomerase, II, inhibitors, inhibits, DNA, type, antitumor, immunosuppressant, synthesis, repair, PIM1, kinase, USP11, ubiquitin, specific, peptidase, 11, chemotherapeutics, Topoisomerase, Pim, Kinase, Deubiquitinating, Enzymes, 4250, Tocris Bioscience
2 Citations for Mitoxantrone dihydrochloride
Citations are publications that use Tocris products. Selected citations for Mitoxantrone dihydrochloride include:
Zhang (2017) The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Mol Cancer Ther 16 1021 PMID: 28265007
Kathawala et al (2015) The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study. Oncotarget 6 510 PMID: 25402202
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Literature in this Area
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.