FPL 64176

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Cat.No. 1403 - FPL 64176 | C22H21NO3 | CAS No. 120934-96-5
Description: Potent CaV1.x activator
Chemical Name: 2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid methyl ester
Purity: ≥99% (HPLC)
Citations (6)
Literature (3)

Biological Activity

Potent activator of L-type Ca2+ channels (EC50 = 16 nM). 40-fold more potent than Bay K 8644 (Cat. No. 1544) as a positive inotrope in guinea pig atria.

Technical Data

M. Wt 347.41
Formula C22H21NO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 120934-96-5
PubChem ID 3423
Smiles COC(=O)C1=C(C)NC(C)=C1C(=O)C1=CC=CC=C1CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 8.69 25
DMSO 17.37 50

Preparing Stock Solutions

The following data is based on the product molecular weight 347.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.76 mL 28.78 mL 57.57 mL
2.5 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.58 mL 2.88 mL 5.76 mL
25 mM 0.12 mL 0.58 mL 1.15 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Baxter et al (1993) Discovery and synthesis of methyl 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: the first examples of a new class of calcium channel activator. J.Med.Chem. 36 2739 PMID: 7692047

Rampe et al (1993) Comparison of the in vitro and in vivo cardiovascular effects of two structurally distinct Ca++ channel activators, BAY K 8644 and FPL 64176. J.Pharmacol.Exp.Ther. 265 1125 PMID: 7685384

Zheng et al (1991) Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations. Mol.Pharmacol. 40 734 PMID: 1719369

If you know of a relevant reference for FPL 64176, please let us know.

View Related Products by Product Action

View all CaV1.x Channel (L-type) Activators

Keywords: FPL 64176, FPL 64176 supplier, Potent, activator, Ca2+, channels, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, FPL64176, Cav1.x, 1403, Tocris Bioscience

6 Citations for FPL 64176

Citations are publications that use Tocris products. Selected citations for FPL 64176 include:

Zhong (2018) Intracellular emetic signaling evoked by the L-type Ca2+ channel agonist FPL64176 in the least shrew (Cryptotis parva). Eur J Pharmacol 834 157 PMID: 29966616

Large et al (2010) Ionic currents in intimal cultured synoviocytes from the rabbit. Am J Physiol Cell Physiol 299 C1180 PMID: 20720182

Armstrong and Drapeau (2013) Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS. Circ Heart Fail 33 1741 PMID: 23345247

Won et al (2012) Characterization of Na+ and Ca2+ channels in zebrafish dorsal root ganglion neurons. PLoS One 7 e42602 PMID: 22880050

Zhang et al (2011) AKAP79/150 signal complexes in G-protein modulation of neuronal ion channels. J Neurosci 31 7199 PMID: 21562284

Landstrom et al (2011) Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. Endocr Relat Cancer 4 214 PMID: 21216834

Do you know of a great paper that uses FPL 64176 from Tocris? Please let us know.

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Literature in this Area

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