FPL 64176

Pricing Availability   Qty
Description: Potent CaV1.x activator
Chemical Name: 2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid methyl ester
Purity: ≥99% (HPLC)
Citations (6)

Biological Activity for FPL 64176

FPL 64176 is a potent activator of L-type Ca2+ channels (EC50 = 16 nM). 40-fold more potent than Bay K 8644 (Cat. No. 1544) as a positive inotrope in guinea pig atria.

Technical Data for FPL 64176

M. Wt 347.41
Formula C22H21NO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 120934-96-5
PubChem ID 3423
Smiles COC(=O)C1=C(C)NC(C)=C1C(=O)C1=CC=CC=C1CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FPL 64176

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 8.69 25
DMSO 17.37 50

Preparing Stock Solutions for FPL 64176

The following data is based on the product molecular weight 347.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.76 mL 28.78 mL 57.57 mL
2.5 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.58 mL 2.88 mL 5.76 mL
25 mM 0.12 mL 0.58 mL 1.15 mL

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Product Datasheets for FPL 64176

Certificate of Analysis / Product Datasheet
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Keywords: FPL 64176, FPL 64176 supplier, Potent, activator, Ca2+, channels, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, FPL64176, Cav1.x, 1403, Tocris Bioscience

6 Citations for FPL 64176

Citations are publications that use Tocris products. Selected citations for FPL 64176 include:

Zhang et al (2011) AKAP79/150 signal complexes in G-protein modulation of neuronal ion channels. J Neurosci 31 7199 PMID: 21562284

Won et al (2012) Characterization of Na+ and Ca2+ channels in zebrafish dorsal root ganglion neurons. PLoS One 7 e42602 PMID: 22880050

Armstrong and Drapeau (2013) Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS. Circ Heart Fail 33 1741 PMID: 23345247

Large et al (2010) Ionic currents in intimal cultured synoviocytes from the rabbit. Am J Physiol Cell Physiol 299 C1180 PMID: 20720182

Do you know of a great paper that uses FPL 64176 from Tocris? Please let us know.

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