FPA 124
Biological Activity
Akt/PKB inhibitor (IC50 = 100 nM) that interacts with the PH and kinase domains. Inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo.
Technical Data
| M. Wt | 381.73 |
| Formula | C11H9Cl2CuN3O2S |
| Storage | Store at +4°C |
| CAS Number | 902779-59-3 |
| PubChem ID | 16034833 |
| InChI Key | HZRXQEVFXXQYFS-VBPDOGLUSA-L |
| Smiles | Cl[Cu]Cl.NC(=S)N\N=C\C1=COC2=C(C=CC=C2)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.82 | 10 | |
| ethanol | 3.82 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 381.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.62 mL | 13.1 mL | 26.2 mL |
| 5 mM | 0.52 mL | 2.62 mL | 5.24 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.62 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets
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References
References are publications that support the products' biological activity.
Barve et al (2006) Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells. J.Med.Chem. 49 3800 PMID: 16789737
If you know of a relevant reference for FPA 124, please let us know.
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Keywords: FPA 124, supplier, Akt, PKB, inhibitors, inhibits, Protein, Kinases, B, FPA124, Akt, (Protein, Kinase, B), Tocris Bioscience
Citations for FPA 124
Citations are publications that use Tocris products.
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Literature in this Area
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
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- Invasion and Metastasis
Kinases Product Listing
A collection of over 400 products for kinase research, the listing includes inhibitors of:
- Receptor Tyrosine Kinases
- Protein Kinases A, C, D and G
- PI-3 Kinase, Akt and mTOR
- MAPK Signaling
- Receptor Serine/Threonine Kinases
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Pathways for FPA 124
