FPA 124

Pricing Availability   Qty
Description: Akt/PKB inhibitor
Chemical Name: Dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamide copper complex
Citations (1)
Pathways (1)

Biological Activity for FPA 124

FPA 124 is an Akt/PKB inhibitor (IC50 = 100 nM) that interacts with the PH and kinase domains. Inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo.

Technical Data for FPA 124

M. Wt 381.73
Formula C11H9Cl2CuN3O2S
Storage Store at +4°C
CAS Number 902779-59-3
PubChem ID 16034833
Smiles Cl[Cu]Cl.NC(=S)N\N=C\C1=COC2=C(C=CC=C2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FPA 124

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 3.82 10
ethanol 3.82 10

Preparing Stock Solutions for FPA 124

The following data is based on the product molecular weight 381.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.2 mL 130.98 mL 261.97 mL
0.5 mM 5.24 mL 26.2 mL 52.39 mL
1 mM 2.62 mL 13.1 mL 26.2 mL
5 mM 0.52 mL 2.62 mL 5.24 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for FPA 124

References are publications that support the biological activity of the product.

Barve et al (2006) Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells. J.Med.Chem. 49 3800 PMID: 16789737

If you know of a relevant reference for FPA 124, please let us know.

View Related Products by Product Action

View all Akt (Protein Kinase B) Inhibitors

Keywords: FPA 124, FPA 124 supplier, Akt, PKB, inhibitors, inhibits, Protein, Kinases, B, FPA124, (Protein, Kinase, B), B/Akt, 2926, Tocris Bioscience

1 Citation for FPA 124

Citations are publications that use Tocris products. Selected citations for FPA 124 include:

Liddell et al (2016) Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. J Neuroinflammation 13 49 PMID: 26920699

Do you know of a great paper that uses FPA 124 from Tocris? Please let us know.

Reviews for FPA 124

There are currently no reviews for this product. Be the first to review FPA 124 and earn rewards!

Have you used FPA 124?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Pathways for FPA 124

Akt Signaling Pathway

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.