FM19G11

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Cat.No. 6653 - FM19G11 | C23H17N3O8 | CAS No. 329932-55-0
Description: HIF α-subunit inhibitor
Chemical Name: 2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate
Purity: ≥98% (HPLC)
Datasheet
Citations
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Literature

Biological Activity

Hypoxia inducible factor (HIF) α-subunit inhibitor (IC50 = 80 nM in hypoxia induced luciferase assay). Inhibits transcriptional activity of HIFα isoforms. Directly regulates expression and inhibits transcriptional activity of pluripotency markers (Sox2 and Oct4) in rodent and human stem cells under hypoxic conditions, driving differentiation. Improves locomotion after severe spinal cord injury in mice, alone or in combination with transplantation of ependymal stem cells of the spinal cord. Also inhibits O6-methylguanine DNA methyltransferase (MGMT) via HIF1α pathway, under normal and hypoxic conditions in glioblastoma cell lines.

Technical Data

M. Wt 463.4
Formula C23H17N3O8
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 329932-55-0
PubChem ID 1730746
InChI Key XVUOIWIIQVGWAJ-UHFFFAOYSA-N
Smiles CC1=CC=C(C(COC(C2=CC=CC(NC(C3=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C3)=O)=C2)=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 463.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.79 mL 21.58 mL
5 mM 0.43 mL 2.16 mL 4.32 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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References

References are publications that support the biological activity of the product.

Moreno-Manzano et al (2010) FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status. J.Biol.Chem. 285 1333 PMID: 19897487

Alastrue-Agudo et al (2018) FM19G11 and ependymal progenitor/stem cell combinatory treatment enhances neuronal preservation and oligodendrogenesis after severe spinal cord injury. Int.J.Mol.Sci. 19 E200 PMID: 29315225

You et al (2018) FM19G11 inhibits O6-methylguanine DNA-methyltransferase expression under both hypoxic and normoxic conditions. Cancer Med PMID: 29761922


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View Related Products by Product Action

View all Hypoxia Inducible Factor (HIF) Inhibitors

Keywords: FM19G11, FM19G11 supplier, hypoxia, inducible, factor, alpha, subunit, HIF1a, HIF2a, HIF3a, inhibits, inhibitors, pluripotency, genes, stemness, Hypoxia, Inducible, Factors, Other, Differentiation, Products, 6653, Tocris Bioscience

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