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Biological Activity for FM19G11
FM19G11 is a hypoxia inducible factor (HIF) α-subunit inhibitor (IC50 = 80 nM in hypoxia induced luciferase assay). Inhibits transcriptional activity of HIFα isoforms. Directly regulates expression and inhibits transcriptional activity of pluripotency markers (Sox2 and Oct4) in rodent and human stem cells under hypoxic conditions, driving differentiation. Improves locomotion after severe spinal cord injury in mice, alone or in combination with transplantation of ependymal stem cells of the spinal cord. Also inhibits O6-methylguanine DNA methyltransferase (MGMT) via HIF1α pathway, under normal and hypoxic conditions in glioblastoma cell lines.
Compound Libraries for FM19G11
Technical Data for FM19G11
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for FM19G11
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for FM19G11
The following data is based on the product molecular weight 463.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.16 mL||10.79 mL||21.58 mL|
|5 mM||0.43 mL||2.16 mL||4.32 mL|
|10 mM||0.22 mL||1.08 mL||2.16 mL|
|50 mM||0.04 mL||0.22 mL||0.43 mL|
References for FM19G11
References are publications that support the biological activity of the product.
Moreno-Manzano et al (2010) FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status. J.Biol.Chem. 285 1333 PMID: 19897487
Alastrue-Agudo et al (2018) FM19G11 and ependymal progenitor/stem cell combinatory treatment enhances neuronal preservation and oligodendrogenesis after severe spinal cord injury. Int.J.Mol.Sci. 19 E200 PMID: 29315225
You et al (2018) FM19G11 inhibits O6-methylguanine DNA-methyltransferase expression under both hypoxic and normoxic conditions. Cancer Med. 7 3292 PMID: 29761922
If you know of a relevant reference for FM19G11, please let us know.
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Keywords: FM19G11, FM19G11 supplier, hypoxia, inducible, factor, alpha, subunit, HIF1a, HIF2a, HIF3a, inhibits, inhibitors, pluripotency, genes, stemness, Hypoxia, Inducible, Factors, Other, Differentiation, Products, 6653, Tocris Bioscience
Citations for FM19G11
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Currently there are no citations for FM19G11. Do you know of a great paper that uses FM19G11 from Tocris? Please let us know.
Reviews for FM19G11
Average Rating: 4 (Based on 1 Review.)
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Literature in this Area
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