Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewFlunitrazepam
Discontinued Product
Flunitrazepam (Cat. No. 4047) has been withdrawn from sale for commercial reasons.
Description: Acts at the benzodiazepene modulatory site
Chemical Name: 5-(2-Fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one
Purity: ≥99% (HPLC)
Biological Activity for Flunitrazepam
Ligand at the GABAA receptor benzodiazepine modulatory site. Exhibits hypnotic effects; also displays anxiolytic and sedative properties.
Technical Data for Flunitrazepam
| M. Wt | 313.28 |
| Formula | C16H12FN3O3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1622-62-4 |
| PubChem ID | 3380 |
| InChI Key | PPTYJKAXVCCBDU-UHFFFAOYSA-N |
| Smiles | CN(C1=CC=C([N+]([O-])=O)C=C1C(C3=CC=CC=C3F)=NC2)C2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Flunitrazepam
References for Flunitrazepam
References are publications that support the biological activity of the product.
Johnston et al (1998) Flunitrazepam rapidly reduces GABAA receptor subunit protein expression via a protein kinase C-dependent mechanism. Br.J.Pharmacol. 124 1338 PMID: 9723942
Merck Index 14 4146
Malanciuc et al (2009) Analytical characterization of flunitra. Farmacia 57 167
View Related Products by Target
View Related Products by Product Action
Keywords: Flunitrazepam, Flunitrazepam supplier, hypnotic, benzodiazepine, gabaa, receptors, modulatory, binding, sites, agonists, GABAA, Receptors, 4047, Tocris Bioscience
Citations for Flunitrazepam
Citations are publications that use Tocris products.
Currently there are no citations for Flunitrazepam.
Reviews for Flunitrazepam
There are currently no reviews for this product. Be the first to review Flunitrazepam and earn rewards!
Have you used Flunitrazepam?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Ion Channel Product Listing
A collection of around 500 products for ion channel research, the listing includes research tools for the study of:
- Ligand-gated ion channels
- Voltage-gated ion channels
- Other Ion Channels
Pain Research Product Guide
A collection of over 280 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Epilepsy Poster
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Pain Poster
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Schizophrenia Poster
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.