Flunitrazepam

Discontinued Product

Flunitrazepam (Cat. No. 4047) has been withdrawn from sale for commercial reasons.
Cat.No. 4047 - Flunitrazepam | C16H12FN3O3 | CAS No. 1622-62-4
Description: Acts at the benzodiazepene modulatory site
Chemical Name: 5-(2-Fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Ligand at the GABAA receptor benzodiazepine modulatory site. Exhibits hypnotic effects; also displays anxiolytic and sedative properties.

Technical Data

M. Wt 313.28
Formula C16H12FN3O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1622-62-4
PubChem ID 3380
InChI Key PPTYJKAXVCCBDU-UHFFFAOYSA-N
Smiles CN(C1=CC=C([N+]([O-])=O)C=C1C(C3=CC=CC=C3F)=NC2)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

References

References are publications that support the biological activity of the product.

Johnston et al (1998) Flunitrazepam rapidly reduces GABAA receptor subunit protein expression via a protein kinase C-dependent mechanism. Br.J.Pharmacol. 124 1338 PMID: 9723942

Merck Index 14 4146

Malanciuc et al (2009) Analytical characterization of flunitrazepam. Farmacia 57 167

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Citations for Flunitrazepam

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Currently there are no citations for Flunitrazepam.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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GABA Receptors

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

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Epilepsy Poster

Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Schizophrenia

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.