FHT 2344

Pricing Availability   Qty
Description: Potent SMARCA2/4 inhibitor
Chemical Name: N-[(1S)-1-(Methoxymethyl)-2-[[4-[3-(1-methyl-1H-pyrazol-3-yl)phenyl]-2-thiazolyl]amino]-2-oxoethyl]-1-(methylsulfonyl)-1H-pyrrole-3-carboxamide
Purity: ≥95% (HPLC)
Literature (4)

Biological Activity for FHT 2344

FHT 2344 is a potent allosteric and ATP-competitive inhibitor of SMARCA2/SMARCA4 ATPases (also known as BRM/BRG1) of the BAF complex (IC50 values are 13.8 and 26.1 nM at SMARCA2 and SMARCA4, respectively). FHT 2344 inhibits SMARCA2 transcriptional activity in a BRG1-mutant cell line and SMARCA4 transcription in a BRM-mutant cell line (IC50 values are 29.8 and 30.2 nM, respectively). Dose-dependently reduces tumor growth in a uveal melanoma xenograft model and suppresses SOX10 transcription.

Licensing Information

Sold under license from Foghorn Therapeutics

Technical Data for FHT 2344

M. Wt 528.6
Formula C23H24N6O5S2
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2468058-90-2
Smiles COC[C@@H](C(NC1=NC(C2=CC(C3=NN(C=C3)C)=CC=C2)=CS1)=O)NC(C4=CN(S(C)(=O)=O)C=C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FHT 2344

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.43 50

Preparing Stock Solutions for FHT 2344

The following data is based on the product molecular weight 528.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.78 mL 18.92 mL 37.84 mL
2.5 mM 0.76 mL 3.78 mL 7.57 mL
5 mM 0.38 mL 1.89 mL 3.78 mL
25 mM 0.08 mL 0.38 mL 0.76 mL

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References for FHT 2344

References are publications that support the biological activity of the product.

Centore et al (2021) Discovery of novel BAF inhibitors for the treatment of transcription factor-driven cancers. Cancer Res. 81 1224

If you know of a relevant reference for FHT 2344, please let us know.

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Keywords: FHT 2344, FHT 2344 supplier, FHT2344, SMARCA, SMARCA2, SMARCA4, potent, inhibitor, inhibitors, BRM, BRG1, BAF, complex, transcription, tumour, tumor, uveal, melanoma, xenograft, SOX10, Bromodomains, Other, ATPases, 7645, Tocris Bioscience

Citations for FHT 2344

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Literature in this Area

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